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Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies

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  • Xianye Tang
  • Gang Liu
  • Jian Kang
  • Yang Hou
  • Fungui Jiang
  • Wen Yuan
  • Jiangang Shi

Abstract

Background: Many observational studies assessed the association between obesity and risk of hip fracture in adults, but reported controversial results. Our goal was to evaluate the association between obesity and risk of hip fracture in adults by conducting a meta-analysis of prospective cohort studies. Methods: Three databases, PubMed, Embase and Web of Science, were searched through May 2012 to identify eligible cohort studies. Either a fixed- or a random-effects model was used to calculate the pooled relative risk (RR) with its 95% confidence interval (95%CI). Results: Fifteen prospective cohort studies involving a total 3,126,313 participants were finally included into this meta-analysis. Overall, adults with obesity compared with the normal weight group had a significantly decreased risk of hip fracture (RR: 0.66, 95% CI 0.57 to 0.77, P

Suggested Citation

  • Xianye Tang & Gang Liu & Jian Kang & Yang Hou & Fungui Jiang & Wen Yuan & Jiangang Shi, 2013. "Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0055077
    DOI: 10.1371/journal.pone.0055077
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    References listed on IDEAS

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    1. Keaton M Nasser & Alejandro Quiñónez Obiols & Stuart L Silverman, 2011. "Identifying Individuals at Risk for Fracture in Guatemala," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-4, November.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Zhen-Jie Wu & Peng Zhao & Bin Liu & Zhen-Chao Yuan, 2016. "Effect of Cigarette Smoking on Risk of Hip Fracture in Men: A Meta-Analysis of 14 Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-11, December.
    2. Jingjing Liang & Yongxin Chen & Jiahua Zhang & Bingjie Ma & Yan Hu & Yi Liu & Suifang Lin & Zheqing Zhang & Yanyan Song, 2020. "Associations of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Chinese Children Aged 6–10 Years," IJERPH, MDPI, vol. 17(5), pages 1-13, March.

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