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Associations of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Chinese Children Aged 6–10 Years

Author

Listed:
  • Jingjing Liang

    (Department of Child Health Care, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China
    These authors equally contributed to this work.)

  • Yongxin Chen

    (Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China
    These authors equally contributed to this work.)

  • Jiahua Zhang

    (Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China)

  • Bingjie Ma

    (Department of Child Health Care, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China)

  • Yan Hu

    (Department of Child Health Care, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China)

  • Yi Liu

    (Department of Child Health Care, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China)

  • Suifang Lin

    (Department of Child Health Care, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China)

  • Zheqing Zhang

    (Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China)

  • Yanyan Song

    (Department of Child Health Care, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China)

Abstract

Although obesity is considered osteoprotective, the effects of body fat and fat distribution on bone tissue after adjusting for the effects of body weight remain uncertain. This study evaluated the relationships between fat mass, fat distribution, and bone mineral status beyond its weight-bearing effect. We recruited 466 children aged 6–10 years in China. Dual-energy X-ray absorptiometry was used to determine the bone mineral density (BMD) and bone mineral content (BMC) in the total body and total body less head (TBLH), as well as the fat mass (FM) and percentage fat mass (%FM) of the total and segmental body. Weight-adjusted measures of FM and %FM were derived using the residual method. After adjusting for the effects of covariates, we observed statistically significant, dose-dependent negative relationships between the TBLH·BMD/BMC and various weight-adjusted measures of body fat ( p for trend: <0.001–0.038). For each standard deviation increment in the weight-adjusted total body, TBLH, trunk and limbs, the size-adjusted BMC decreased approximately 9.44, 9.28, 8.13, and 6.65 g in boys, respectively, and by approximately 13.74, 13.71, 7.84, and 12.95 g in girls, respectively. Significant inverse associations between FM accumulation in the total body and most body parts with the BMD/BMC were observed in both boys and girls after adjusting for weight and potential confounders.

Suggested Citation

  • Jingjing Liang & Yongxin Chen & Jiahua Zhang & Bingjie Ma & Yan Hu & Yi Liu & Suifang Lin & Zheqing Zhang & Yanyan Song, 2020. "Associations of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Chinese Children Aged 6–10 Years," IJERPH, MDPI, vol. 17(5), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1763-:d:330064
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    References listed on IDEAS

    as
    1. Yan-hua Liu & Ying Xu & Ya-bin Wen & Ke Guan & Wen-hua Ling & Li-ping He & Yi-xiang Su & Yu-ming Chen, 2013. "Association of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Middle-Aged Chinese Adults: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-9, May.
    2. Xianye Tang & Gang Liu & Jian Kang & Yang Hou & Fungui Jiang & Wen Yuan & Jiangang Shi, 2013. "Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
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