IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0055019.html
   My bibliography  Save this article

The MDM2 309T>G Polymorphism and Ovarian Cancer Risk: A Meta-Analysis of 1534 Cases and 2211 Controls

Author

Listed:
  • Ying-Yu Ma
  • Tian-Pei Guan
  • Hai-Bo Yao
  • Sheng Yu
  • Le-Gao Chen
  • Ying-Jie Xia
  • Xu-Jun He
  • Hui-Ju Wang
  • Xiao-Ting Jiang
  • Hou-Quan Tao

Abstract

Background: Recently, there have been a number of studies on the association between MDM2 (Murine Double Minute 2) 309 polymorphism and ovarian cancer risk. However, the results of previous reports remain controversial and ambiguous. Thus, we performed a meta-analysis to explore more precisely the association between MDM2 309 polymorphism and the risk of ovarian cancer. Methods: A meta-analysis was performed to examine the association between MDM2 309T>G polymorphism and ovarian cancer risk. Odds ratio (OR) and its 95% confidence interval (CI) were used for statistical analysis. Results: Our publication search identified a total of 6 studies with 1534 cases and 2211 controls. No significant association was found between MDM2 309T>G polymorphism and ovarian cancer risk in total population analysis. In the subgroup meta-analysis by ethnicity, a negative association was shown in Asian subgroup (G vs. T OR = 0.774, 95% CI = 0.628–0.955, P = 0.017, Phet = 0.327; GG vs. TT: OR = 0.601, 95% CI = 0.395–0.914, P = 0.017, Phet = 0.417; dominant model TG+GG vs. TT: OR = 0.661, 95% CI = 0.468–0.934, P = 0.019, Phet = 0.880), and no significant association in any genetic models among Caucasians was observed. Conclusions: This meta-analysis provides evidence for the association between MDM2 309 polymorphism and ovarian cancer risk, supporting the hypothesis that MDM2 SNP309 G allele acts as an important ovarian cancer protective factor in Asians but not in Caucasians.

Suggested Citation

  • Ying-Yu Ma & Tian-Pei Guan & Hai-Bo Yao & Sheng Yu & Le-Gao Chen & Ying-Jie Xia & Xu-Jun He & Hui-Ju Wang & Xiao-Ting Jiang & Hou-Quan Tao, 2013. "The MDM2 309T>G Polymorphism and Ovarian Cancer Risk: A Meta-Analysis of 1534 Cases and 2211 Controls," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-6, January.
    • Handle: RePEc:plo:pone00:0055019
    DOI: 10.1371/journal.pone.0055019
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055019
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055019&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0055019?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ygal Haupt & Ruth Maya & Anat Kazaz & Moshe Oren, 1997. "Mdm2 promotes the rapid degradation of p53," Nature, Nature, vol. 387(6630), pages 296-299, May.
    2. Michael H. G. Kubbutat & Stephen N. Jones & Karen H. Vousden, 1997. "Regulation of p53 stability by Mdm2," Nature, Nature, vol. 387(6630), pages 299-303, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Clara Morral & Arshad Ayyaz & Hsuan-Cheng Kuo & Mardi Fink & Ioannis I. Verginadis & Andrea R. Daniel & Danielle N. Burner & Lucy M. Driver & Sloane Satow & Stephanie Hasapis & Reem Ghinnagow & Lixia , 2024. "p53 promotes revival stem cells in the regenerating intestine after severe radiation injury," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Bo Liu & Shiwei Yan & Xingfa Gao, 2011. "Noise Amplification in Human Tumor Suppression following Gamma Irradiation," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-9, August.
    3. Tomoe Ueyama & Shu Nakao & Tasuku Tsukamoto & Dai Ihara & Yukihiro Harada & Yuka Akagi & Sae Nakagawa & Teruhisa Kawamura & Takahiro Sogo & Yasuyuki S Kida, 2018. "PTEN/Akt Axis is Involved in Somatic Cell Reprogramming to Mouse iPS Cells," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8789-8795, December.
    4. Mu Li & Aaron Zhong & Youjun Wu & Mega Sidharta & Michael Beaury & Xiaolan Zhao & Lorenz Studer & Ting Zhou, 2022. "Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Jing Li & Yang Tang & Liu Huang & Qianqian Yu & Guangyuan Hu & Xianglin Yuan, 2016. "Genetic Variants in the p14ARF/MDM2/TP53 Pathway Are Associated with the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated with Radical Resection," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-11, July.
    6. Hao Yan & Wentong Wu & Yuhuai Hu & Jinjin Li & Jiangxin Xu & Xueqin Chen & Zhifei Xu & Xiaochun Yang & Bo Yang & Qiaojun He & Peihua Luo, 2023. "Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Bottani, Samuel & Grammaticos, Basile, 2008. "A simple model of genetic oscillations through regulated degradation," Chaos, Solitons & Fractals, Elsevier, vol. 38(5), pages 1468-1482.
    8. Masayo Inoue & Katsuhisa Horimoto, 2017. "Relationship between regulatory pattern of gene expression level and gene function," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-14, May.
    9. Yong Ma & Jianmin Bian & Hongyong Cao, 2013. "MDM2 SNP309 rs2279744 Polymorphism and Gastric Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-5, February.
    10. Kelvin Ka-lok Wu & Xiaofan Xu & Manyin Wu & Xiaomu Li & Moinul Hoque & Gloria Hoi Yee Li & Qizhou Lian & Kekao Long & Tongxi Zhou & Hailong Piao & Aimin Xu & Hannah Xiaoyan Hui & Kenneth King-yip Chen, 2024. "MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0055019. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.