IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0050910.html
   My bibliography  Save this article

CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects

Author

Listed:
  • Yan-yan Li
  • Chuan-wei Zhou
  • Jian Xu
  • Yun Qian
  • Bei Wang

Abstract

Background: Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting. Objective and methods: A meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed– or random–effects model. Results: A significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11–1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26–3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820–0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130–1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070–1.243, P = 1.0×10−10) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956–1.131, P = 0.361). Conclusions: A significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF.

Suggested Citation

  • Yan-yan Li & Chuan-wei Zhou & Jian Xu & Yun Qian & Bei Wang, 2012. "CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
  • Handle: RePEc:plo:pone00:0050910
    DOI: 10.1371/journal.pone.0050910
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050910
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050910&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0050910?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Stanley Nattel, 2002. "New ideas about atrial fibrillation 50 years on," Nature, Nature, vol. 415(6868), pages 219-226, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wu, Mengjia & Zhang, Yi & Zhang, Guangquan & Lu, Jie, 2021. "Exploring the genetic basis of diseases through a heterogeneous bibliometric network: A methodology and case study," Technological Forecasting and Social Change, Elsevier, vol. 164(C).
    2. Yan Pi & Li-li Zhang & Kai Chang & Lu Guo & Yun Liu & Bing-hu Li & Xiao-jie Cao & Shao-qiong Liao & Chang-yue Gao & Jing-cheng Li, 2013. "Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Michael A Colman, 2019. "Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation," PLOS Computational Biology, Public Library of Science, vol. 15(8), pages 1-34, August.
    2. Daniel M Lombardo & Flavio H Fenton & Sanjiv M Narayan & Wouter-Jan Rappel, 2016. "Comparison of Detailed and Simplified Models of Human Atrial Myocytes to Recapitulate Patient Specific Properties," PLOS Computational Biology, Public Library of Science, vol. 12(8), pages 1-15, August.
    3. Eberhard P Scholz & Paola Carrillo-Bustamante & Fathima Fischer & Mathias Wilhelms & Edgar Zitron & Olaf Dössel & Hugo A Katus & Gunnar Seemann, 2013. "Rotor Termination Is Critically Dependent on Kinetic Properties of IKur Inhibitors in an In Silico Model of Chronic Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.
    4. Cui, Xingran & Chang, Hung-Chi & Lin, Lian-Yu & Yu, Chih-Chieh & Hsieh, Wan-Hsin & Li, Weihui & Peng, Chung-Kang & Lin, Jiunn-Lee & Lo, Men-Tzung, 2019. "Prediction of atrial fibrillation recurrence before catheter ablation using an adaptive nonlinear and non-stationary surface ECG analysis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 514(C), pages 9-19.
    5. Narin, Ali & Isler, Yalcin & Ozer, Mahmut & Perc, Matjaž, 2018. "Early prediction of paroxysmal atrial fibrillation based on short-term heart rate variability," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 509(C), pages 56-65.
    6. Feng Ou & Nini Rao & Xudong Jiang & Mengyao Qian & Wei Feng & Lixue Yin & Xu Chen, 2013. "Analysis on Differential Gene Expression Data for Prediction of New Biological Features in Permanent Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-8, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0050910. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.