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On-Lattice Simulation of T Cell Motility, Chemotaxis, and Trafficking in the Lymph Node Paracortex

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  • Gib Bogle
  • P Rod Dunbar

Abstract

Agent-based simulation is a powerful method for investigating the complex interplay of the processes occurring in a lymph node during an adaptive immune response. We have previously established an agent-based modeling framework for the interactions between T cells and dendritic cells within the paracortex of lymph nodes. This model simulates in three dimensions the “random-walk” T cell motility observed in vivo, so that cells interact in space and time as they process signals and commit to action such as proliferation. On-lattice treatment of cell motility allows large numbers of densely packed cells to be simulated, so that the low frequency of T cells capable of responding to a single antigen can be dealt with realistically. In this paper we build on this model by incorporating new numerical methods to address the crucial processes of T cell ingress and egress, and chemotaxis, within the lymph node. These methods enable simulation of the dramatic expansion and contraction of the T cell population in the lymph node paracortex during an immune response. They also provide a novel probabilistic method to simulate chemotaxis that will be generally useful in simulating other biological processes in which chemotaxis is an important feature.

Suggested Citation

  • Gib Bogle & P Rod Dunbar, 2012. "On-Lattice Simulation of T Cell Motility, Chemotaxis, and Trafficking in the Lymph Node Paracortex," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-13, September.
  • Handle: RePEc:plo:pone00:0045258
    DOI: 10.1371/journal.pone.0045258
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    References listed on IDEAS

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    1. Thorsten R. Mempel & Sarah E. Henrickson & Ulrich H. von Andrian, 2004. "T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases," Nature, Nature, vol. 427(6970), pages 154-159, January.
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