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Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers

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  • Shin-Ichiro Nakayama
  • Shoi Shi
  • Masaki Tateno
  • Masakazu Shimada
  • K Ryo Takahasi

Abstract

Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations. This prediction may not always be true when we consider a potential difference in deleterious mutation rate between selfers and outcrossers. By analyzing the evolutionary stability of selfing and outcrossing in an infinite population, we found that the genome-wide deleterious mutation rate would be lower in selfing than in outcrossing organisms. When this difference in mutation rate was included in simulations, we found that in a small population, mutations accumulated more slowly under selfing rather than outcrossing. This result suggests that under frequent and intense bottlenecks, a selfing population may have a lower risk of genetic extinction than an outcrossing population.

Suggested Citation

  • Shin-Ichiro Nakayama & Shoi Shi & Masaki Tateno & Masakazu Shimada & K Ryo Takahasi, 2012. "Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-6, March.
    • Handle: RePEc:plo:pone00:0033541
    DOI: 10.1371/journal.pone.0033541
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    References listed on IDEAS

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    1. Cathy Haag-Liautard & Mark Dorris & Xulio Maside & Steven Macaskill & Daniel L. Halligan & Brian Charlesworth & Peter D. Keightley, 2007. "Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila," Nature, Nature, vol. 445(7123), pages 82-85, January.
    2. Levi T. Morran & Michelle D. Parmenter & Patrick C. Phillips, 2009. "Mutation load and rapid adaptation favour outcrossing over self-fertilization," Nature, Nature, vol. 462(7271), pages 350-352, November.
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