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Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

Author

Listed:
  • Cathy Haag-Liautard

    (University of Edinburgh)

  • Mark Dorris

    (University of Edinburgh)

  • Xulio Maside

    (University of Edinburgh
    Universidade de Santiago, S. Francisco s/n)

  • Steven Macaskill

    (University of Edinburgh
    Peter MacCallum Cancer Centre)

  • Daniel L. Halligan

    (University of Edinburgh)

  • Brian Charlesworth

    (University of Edinburgh)

  • Peter D. Keightley

    (University of Edinburgh)

Abstract

Mutation by numbers Many theoretical calculations in genetics rely on an estimate of u, the mutation rate per nucleotide in the genome, but its value has been controversial because only indirect estimates have previously been available. For the first time a direct estimate of the mutation rate per base pair has been obtained in Drosophila, based on scanning the genome of mutation accumulation lines for mutational changes in the DNA. The new estimate is relatively high, implying that selection against deleterious mutations favours the evolution of sex and recombination.

Suggested Citation

  • Cathy Haag-Liautard & Mark Dorris & Xulio Maside & Steven Macaskill & Daniel L. Halligan & Brian Charlesworth & Peter D. Keightley, 2007. "Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila," Nature, Nature, vol. 445(7123), pages 82-85, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7123:d:10.1038_nature05388
    DOI: 10.1038/nature05388
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    Cited by:

    1. Benger, Etam & Sella, Guy, 2013. "Modeling the effect of changing selective pressures on polymorphism and divergence," Theoretical Population Biology, Elsevier, vol. 85(C), pages 73-85.
    2. Junhui Peng & Li Zhao, 2024. "The origin and structural evolution of de novo genes in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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