IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0020650.html
   My bibliography  Save this article

Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder

Author

Listed:
  • Premananda Indic
  • Paola Salvatore
  • Carlo Maggini
  • Stefano Ghidini
  • Gabriella Ferraro
  • Ross J Baldessarini
  • Greg Murray

Abstract

Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

Suggested Citation

  • Premananda Indic & Paola Salvatore & Carlo Maggini & Stefano Ghidini & Gabriella Ferraro & Ross J Baldessarini & Greg Murray, 2011. "Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0020650
    DOI: 10.1371/journal.pone.0020650
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020650
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020650&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0020650?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Erik R Hauge & Jan Øystein Berle & Ketil J Oedegaard & Fred Holsten & Ole Bernt Fasmer, 2011. "Nonlinear Analysis of Motor Activity Shows Differences between Schizophrenia and Depression: A Study Using Fourier Analysis and Sample Entropy," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-10, January.
    2. Urs Frey & Tanja Brodbeck & Arnab Majumdar & D. Robin Taylor & G. Ian Town & Michael Silverman & Béla Suki, 2005. "Risk of severe asthma episodes predicted from fluctuation analysis of airway function," Nature, Nature, vol. 438(7068), pages 667-670, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hadaeghi, Fatemeh & Hashemi Golpayegani, Seyed Mohammad Reza & Gardini, Laura, 2016. "A non-autonomous system leading to cyclic chaotic sets to model physiological rhythms," Applied Mathematics and Computation, Elsevier, vol. 281(C), pages 343-355.
    2. Muslim, Roni & NQZ, Rinto Anugraha & Khalif, Muhammad Ardhi, 2024. "Mass media and its impact on opinion dynamics of the nonlinear q-voter model," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 633(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ole Bernt Fasmer & Erlend Eindride Fasmer & Kristin Mjeldheim & Wenche Førland & Vigdis Elin Giæver Syrstad & Petter Jakobsen & Jan Øystein Berle & Tone E G Henriksen & Zahra Sepasdar & Erik R Hauge &, 2020. "Diurnal variation of motor activity in adult ADHD patients analyzed with methods from graph theory," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-18, November.
    2. Chung‐Min Liao & Nan‐Hung Hsieh & Chia‐Pin Chio & Szu‐Chieh Chen, 2010. "Assessing the Exacerbations Risk of Influenza‐Associated Chronic Occupational Asthma," Risk Analysis, John Wiley & Sons, vol. 30(7), pages 1062-1075, July.
    3. Georgette Stern & Julia Beel & Béla Suki & Mike Silverman & Jenny Westaway & Mateja Cernelc & David Baldwin & Urs Frey, 2009. "Long-Range Correlations in Rectal Temperature Fluctuations of Healthy Infants during Maturation," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-9, July.
    4. Karoline Krane-Gartiser & Tone Elise Gjotterud Henriksen & Gunnar Morken & Arne Vaaler & Ole Bernt Fasmer, 2014. "Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    5. Kerstin Jost & Isabelle Pramana & Edgar Delgado-Eckert & Nitin Kumar & Alexandre N Datta & Urs Frey & Sven M Schulzke, 2017. "Dynamics and complexity of body temperature in preterm infants nursed in incubators," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-15, April.
    6. Petter Jakobsen & Enrique Garcia-Ceja & Michael Riegler & Lena Antonsen Stabell & Tine Nordgreen & Jim Torresen & Ole Bernt Fasmer & Ketil Joachim Oedegaard, 2020. "Applying machine learning in motor activity time series of depressed bipolar and unipolar patients compared to healthy controls," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-16, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0020650. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.