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Risk of severe asthma episodes predicted from fluctuation analysis of airway function

Author

Listed:
  • Urs Frey

    (University Hospital of Berne)

  • Tanja Brodbeck

    (University Hospital of Berne)

  • Arnab Majumdar

    (Boston University)

  • D. Robin Taylor

    (Dunedin/Christchurch Schools of Medicine, University of Otago)

  • G. Ian Town

    (Dunedin/Christchurch Schools of Medicine, University of Otago)

  • Michael Silverman

    (Leicester University)

  • Béla Suki

    (Boston University)

Abstract

Keep track of asthma Chronic asthma is an inflammatory disease of the airways that erupts at unpredictable intervals as asthma attacks or episodes caused by severe airway obstruction. The ability to predict the long-term risk of asthma episodes would provide a much-needed quantitative basis for evaluating new drugs and refining treatment regimes. That was the aim of an analysis of the fluctuation of airway obstruction in a population of 80 asthmatics over an 18-month period. The results show that asthma is a dynamic process that can develop a long-range pattern. Specifically, regular use of a long-acting bronchodilator (salmeterol) decreased risk of airway obstruction but a widely used short-acting bronchodilator (albuterol) increased the long-term risk.

Suggested Citation

  • Urs Frey & Tanja Brodbeck & Arnab Majumdar & D. Robin Taylor & G. Ian Town & Michael Silverman & Béla Suki, 2005. "Risk of severe asthma episodes predicted from fluctuation analysis of airway function," Nature, Nature, vol. 438(7068), pages 667-670, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7068:d:10.1038_nature04176
    DOI: 10.1038/nature04176
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    Cited by:

    1. Georgette Stern & Julia Beel & Béla Suki & Mike Silverman & Jenny Westaway & Mateja Cernelc & David Baldwin & Urs Frey, 2009. "Long-Range Correlations in Rectal Temperature Fluctuations of Healthy Infants during Maturation," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-9, July.
    2. Chung‐Min Liao & Nan‐Hung Hsieh & Chia‐Pin Chio & Szu‐Chieh Chen, 2010. "Assessing the Exacerbations Risk of Influenza‐Associated Chronic Occupational Asthma," Risk Analysis, John Wiley & Sons, vol. 30(7), pages 1062-1075, July.
    3. Kerstin Jost & Isabelle Pramana & Edgar Delgado-Eckert & Nitin Kumar & Alexandre N Datta & Urs Frey & Sven M Schulzke, 2017. "Dynamics and complexity of body temperature in preterm infants nursed in incubators," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-15, April.
    4. Premananda Indic & Paola Salvatore & Carlo Maggini & Stefano Ghidini & Gabriella Ferraro & Ross J Baldessarini & Greg Murray, 2011. "Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-8, May.

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