The impact of vector migration on the effectiveness of strategies to control gambiense human African trypanosomiasis

Background: Several modeling studies have been undertaken to assess the feasibility of the WHO goal of eliminating gambiense human African trypanosomiasis (g-HAT) by 2030. However, these studies have generally overlooked the effect of vector migration on disease transmission and control. Here, we evaluated the impact of vector migration on the feasibility of interrupting transmission in different g-HAT foci. Methods: We developed a g-HAT transmission model of a single tsetse population cluster that accounts for migration of tsetse fly into this population. We used a model calibration approach to constrain g-HAT incidence to ranges expected for high, moderate and low transmission settings, respectively. We used the model to evaluate the effectiveness of current intervention measures, including medical intervention through enhanced screening and treatment, and vector control, for interrupting g-HAT transmission in disease foci under each transmission setting. Results: We showed that, in low transmission settings, under enhanced medical intervention alone, at least 70% treatment coverage is needed to interrupt g-HAT transmission within 10 years. In moderate transmission settings, a combination of medical intervention and a vector control measure with a daily tsetse mortality greater than 0.03 is required to achieve interruption of disease transmission within 10 years. In high transmission settings, interruption of disease transmission within 10 years requires a combination of at least 70% medical intervention coverage and at least 0.05 tsetse daily mortality rate from vector control. However, the probability of achieving elimination in high transmission settings decreases with an increased tsetse migration rate. Conclusion: Our results suggest that the WHO 2030 goal of G-HAT elimination is, at least in theory, achievable. But the presence of tsetse migration may reduce the probability of interrupting g-HAT transmission in moderate and high transmission foci. Therefore, optimal vector control programs should incorporate monitoring and controlling of vector density in buffer areas around foci of g-HAT control efforts. Author summary: Gambian human African trypanosomiasis (g-HAT), also known as sleeping sickness, is a vector-borne parasitic disease transmitted by tsetse flies. If untreated, g-HAT infection will usually result in death. Recently, the World Health Organization (WHO) has targeted g-HAT for elimination through achieving interruption of transmission by 2030. To help inform elimination efforts, mathematical models have been used to evaluate the feasibility of the WHO goals in different g-HAT transmission foci. However, these mathematical models have generally ignored the role that tsetse migration may have in the spread and reemergence of g-HAT. Using a mathematical model, we evaluate the impact of tsetse migration on the effectiveness of current intervention measures for achieving interruption of g-HAT transmission in different transmission foci. We consider different interventions such as enhanced screening and treatment and vector control. We show that vector control has a great potential for reducing transmission. Still, the presence and intensity of tsetse migration can undermine its effectiveness for interrupting disease transmission, especially in high transmission foci. Our results indicate the need of accounting for tsetse surveillance and migration data in designing vector control efforts for g-HAT elimination.