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Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma

Author

Listed:
  • Leonieke M E van Koolwijk
  • Wishal D Ramdas
  • M Kamran Ikram
  • Nomdo M Jansonius
  • Francesca Pasutto
  • Pirro G Hysi
  • Stuart Macgregor
  • Sarah F Janssen
  • Alex W Hewitt
  • Ananth C Viswanathan
  • Jacoline B ten Brink
  • S Mohsen Hosseini
  • Najaf Amin
  • Dominiek D G Despriet
  • Jacqueline J M Willemse-Assink
  • Rogier Kramer
  • Fernando Rivadeneira
  • Maksim Struchalin
  • Yurii S Aulchenko
  • Nicole Weisschuh
  • Matthias Zenkel
  • Christian Y Mardin
  • Eugen Gramer
  • Ulrich Welge-Lüssen
  • Grant W Montgomery
  • Francis Carbonaro
  • Terri L Young
  • The DCCT/EDIC Research Group
  • Céline Bellenguez
  • Peter McGuffin
  • Paul J Foster
  • Fotis Topouzis
  • Paul Mitchell
  • Jie Jin Wang
  • Tien Y Wong
  • Monika A Czudowska
  • Albert Hofman
  • Andre G Uitterlinden
  • Roger C W Wolfs
  • Paulus T V M de Jong
  • Ben A Oostra
  • Andrew D Paterson
  • Wellcome Trust Case Control Consortium 2
  • David A Mackey
  • Arthur A B Bergen
  • André Reis
  • Christopher J Hammond
  • Johannes R Vingerling
  • Hans G Lemij
  • Caroline C W Klaver
  • Cornelia M van Duijn

Abstract

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed a genome-wide association study for IOP in 11,972 participants from 4 independent population-based studies in The Netherlands. We replicated our findings in 7,482 participants from 4 additional cohorts from the UK, Australia, Canada, and the Wellcome Trust Case-Control Consortium 2/Blue Mountains Eye Study. IOP was significantly associated with rs11656696, located in GAS7 at 17p13.1 (p = 1.4×10−8), and with rs7555523, located in TMCO1 at 1q24.1 (p = 1.6×10−8). In a meta-analysis of 4 case-control studies (total N = 1,432 glaucoma cases), both variants also showed evidence for association with glaucoma (p = 2.4×10−2 for rs11656696 and p = 9.1×10−4 for rs7555523). GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina. Both genes functionally interact with known glaucoma disease genes. These data suggest that we have identified two clinically relevant genes involved in IOP regulation. Author Summary: Glaucoma is a major eye disease in the elderly and is the second leading cause of blindness worldwide. The numerous familial glaucoma cases, as well as evidence from epidemiological and twin studies, strongly support a genetic component in developing glaucoma. However, it has proven difficult to identify the specific genes involved. Intraocular pressure (IOP) is the major risk factor for glaucoma and the only target for the current glaucoma therapy. IOP has been shown to be highly heritable. We investigated the role of common genetic variants in IOP by performing a genome-wide association study. Discovery analyses in 11,972 participants and subsequent replication analyses in a further 7,482 participants yielded two common genetic variants that were associated with IOP. The first (rs11656696) is located in GAS7 at chromosome 17, the second (rs7555523) in TMCO1 at chromosome 1. Both variants were associated with glaucoma in a meta-analysis of 4 case-control studies. GAS7 and TMCO1 are expressed in the ocular tissues that are involved in glaucoma. Both genes functionally interact with the known glaucoma disease genes. These data suggest that we have identified two genes involved in IOP regulation and glaucomatous neuropathy.

Suggested Citation

  • Leonieke M E van Koolwijk & Wishal D Ramdas & M Kamran Ikram & Nomdo M Jansonius & Francesca Pasutto & Pirro G Hysi & Stuart Macgregor & Sarah F Janssen & Alex W Hewitt & Ananth C Viswanathan & Jacoli, 2012. "Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma," PLOS Genetics, Public Library of Science, vol. 8(5), pages 1-14, May.
  • Handle: RePEc:plo:pgen00:1002611
    DOI: 10.1371/journal.pgen.1002611
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    References listed on IDEAS

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    1. Najaf Amin & Cornelia M van Duijn & Yurii S Aulchenko, 2007. "A Genomic Background Based Method for Association Analysis in Related Individuals," PLOS ONE, Public Library of Science, vol. 2(12), pages 1-7, December.
    2. Yi Lu & David P Dimasi & Pirro G Hysi & Alex W Hewitt & Kathryn P Burdon & Tze'Yo Toh & Jonathan B Ruddle & Yi Ju Li & Paul Mitchell & Paul R Healey & Grant W Montgomery & Narelle Hansell & Timothy D , 2010. "Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness," PLOS Genetics, Public Library of Science, vol. 6(5), pages 1-10, May.
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    1. Yibo Yu & Yu Weng & Jing Guo & Guangdi Chen & Ke Yao, 2013. "Association of Glutathione S transferases Polymorphisms with Glaucoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.

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