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Ethnic and Mouse Strain Differences in Central Corneal Thickness and Association with Pigmentation Phenotype

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Listed:
  • David P Dimasi
  • Alex W Hewitt
  • Kenneth Kagame
  • Sam Ruvama
  • Ludovica Tindyebwa
  • Bastien Llamas
  • Kirsty A Kirk
  • Paul Mitchell
  • Kathryn P Burdon
  • Jamie E Craig

Abstract

The cornea is a transparent structure that permits the refraction of light into the eye. Evidence from a range of studies indicates that central corneal thickness (CCT) is strongly genetically determined. Support for a genetic component comes from data showing significant variation in CCT between different human ethnic groups. Interestingly, these studies also appear to show that skin pigmentation may influence CCT. To validate these observations, we undertook the first analysis of CCT in an oculocutaneous albinism (OCA) and Ugandan cohort, populations with distinct skin pigmentation phenotypes. There was a significant difference in the mean CCT of the OCA, Ugandan and Australian-Caucasian cohorts (Ugandan: 517.3±37 µm; Caucasian: 539.7±32.8 µm, OCA: 563.3±37.2 µm; p

Suggested Citation

  • David P Dimasi & Alex W Hewitt & Kenneth Kagame & Sam Ruvama & Ludovica Tindyebwa & Bastien Llamas & Kirsty A Kirk & Paul Mitchell & Kathryn P Burdon & Jamie E Craig, 2011. "Ethnic and Mouse Strain Differences in Central Corneal Thickness and Association with Pigmentation Phenotype," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0022103
    DOI: 10.1371/journal.pone.0022103
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    References listed on IDEAS

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    1. Yi Lu & David P Dimasi & Pirro G Hysi & Alex W Hewitt & Kathryn P Burdon & Tze'Yo Toh & Jonathan B Ruddle & Yi Ju Li & Paul Mitchell & Paul R Healey & Grant W Montgomery & Narelle Hansell & Timothy D , 2010. "Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness," PLOS Genetics, Public Library of Science, vol. 6(5), pages 1-10, May.
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