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Association of Glutathione S transferases Polymorphisms with Glaucoma: A Meta-Analysis

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  • Yibo Yu
  • Yu Weng
  • Jing Guo
  • Guangdi Chen
  • Ke Yao

Abstract

Background: Glutathione S transferase (GST) polymorphisms have been considered risk factors for the development of glaucoma, including primary open angle glaucoma (POAG) and other types of glaucoma. However, the results remain controversial. In this study, we have conducted a meta-analysis to assess the association between polymorphisms of GSTM1, GSTT1 and GSTP1 and glaucoma risk. Methods: Published literature from PubMed and other databases were retrieved. All studies evaluating the association between GSTM1, GSTT1 and GSTP1 polymorphisms and glaucoma risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model. Results: Twelve studies on GSTM1 (1109 cases and 844 controls), ten studies on GSTT1 (709 cases and 664 controls) and four studies on GSTP1 (543 cases and 511 controls) were included. By pooling all the studies, either GSTM1 or GSTT1 null polymorphism was not associated with a POAG risk, and this negative association maintained in Caucasian. The GSTP1 Ile 105 Val polymorphism was significantly correlated with increased POAG risk among Caucasian in a recessive model (Val/Val vs. Ile/Ile+Ile/Val: OR, 1.62, 95%CI: 1.00–2.61). Interestingly, increased glaucoma risk was associated with the combined GSTM1 and GSTT1 null genotypes (OR, 2.20; 95% CI, 1.47–3.31), and with the combined GSTM1 null and GSTP1 Val genotypes (OR, 1.86; 95% CI, 1.15–3.01). Conclusions: This meta-analysis suggests that combinations of GST polymorphisms are associated with glaucoma risk. Given the limited sample size, the associations between single GST polymorphism and glaucoma risk await further investigation.

Suggested Citation

  • Yibo Yu & Yu Weng & Jing Guo & Guangdi Chen & Ke Yao, 2013. "Association of Glutathione S transferases Polymorphisms with Glaucoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.
  • Handle: RePEc:plo:pone00:0054037
    DOI: 10.1371/journal.pone.0054037
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    1. Leonieke M E van Koolwijk & Wishal D Ramdas & M Kamran Ikram & Nomdo M Jansonius & Francesca Pasutto & Pirro G Hysi & Stuart Macgregor & Sarah F Janssen & Alex W Hewitt & Ananth C Viswanathan & Jacoli, 2012. "Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma," PLOS Genetics, Public Library of Science, vol. 8(5), pages 1-14, May.
    2. Janey L Wiggs & Brian L Yaspan & Michael A Hauser & Jae H Kang & R Rand Allingham & Lana M Olson & Wael Abdrabou & Bao J Fan & Dan Y Wang & Wendy Brodeur & Donald L Budenz & Joseph Caprioli & Andrew C, 2012. "Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma," PLOS Genetics, Public Library of Science, vol. 8(4), pages 1-12, April.
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    1. Anne Senabouth & Maciej Daniszewski & Grace E. Lidgerwood & Helena H. Liang & Damián Hernández & Mehdi Mirzaei & Stacey N. Keenan & Ran Zhang & Xikun Han & Drew Neavin & Louise Rooney & Maria Isabel G, 2022. "Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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