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A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

Author

Listed:
  • Yukinori Okada
  • Kenichi Shimane
  • Yuta Kochi
  • Tomoko Tahira
  • Akari Suzuki
  • Koichiro Higasa
  • Atsushi Takahashi
  • Tetsuya Horita
  • Tatsuya Atsumi
  • Tomonori Ishii
  • Akiko Okamoto
  • Keishi Fujio
  • Michito Hirakata
  • Hirofumi Amano
  • Yuya Kondo
  • Satoshi Ito
  • Kazuki Takada
  • Akio Mimori
  • Kazuyoshi Saito
  • Makoto Kamachi
  • Yasushi Kawaguchi
  • Katsunori Ikari
  • Osman Wael Mohammed
  • Koichi Matsuda
  • Chikashi Terao
  • Koichiro Ohmura
  • Keiko Myouzen
  • Naoya Hosono
  • Tatsuhiko Tsunoda
  • Norihiro Nishimoto
  • Tsuneyo Mimori
  • Fumihiko Matsuda
  • Yoshiya Tanaka
  • Takayuki Sumida
  • Hisashi Yamanaka
  • Yoshinari Takasaki
  • Takao Koike
  • Takahiko Horiuchi
  • Kenshi Hayashi
  • Michiaki Kubo
  • Naoyuki Kamatani
  • Ryo Yamada
  • Yusuke Nakamura
  • Kazuhiko Yamamoto

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage. Although recent genome-wide association studies (GWAS) have contributed to discovery of SLE susceptibility genes, few studies has been performed in Asian populations. Here, we report a GWAS for SLE examining 891 SLE cases and 3,384 controls and multi-stage replication studies examining 1,387 SLE cases and 28,564 controls in Japanese subjects. Considering that expression quantitative trait loci (eQTLs) have been implicated in genetic risks for autoimmune diseases, we integrated an eQTL study into the results of the GWAS. We observed enrichments of cis-eQTL positive loci among the known SLE susceptibility loci (30.8%) compared to the genome-wide SNPs (6.9%). In addition, we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with SLE susceptibility (rs340630; P = 8.3×10−9, odds ratio = 1.21). The risk A allele of rs340630 demonstrated a cis-eQTL effect on the AFF1 transcript with enhanced expression levels (P

Suggested Citation

  • Yukinori Okada & Kenichi Shimane & Yuta Kochi & Tomoko Tahira & Akari Suzuki & Koichiro Higasa & Atsushi Takahashi & Tetsuya Horita & Tatsuya Atsumi & Tomonori Ishii & Akiko Okamoto & Keishi Fujio & M, 2012. "A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese," PLOS Genetics, Public Library of Science, vol. 8(1), pages 1-10, January.
    • Handle: RePEc:plo:pgen00:1002455
    DOI: 10.1371/journal.pgen.1002455
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    References listed on IDEAS

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    2. Soumya Raychaudhuri & Robert M Plenge & Elizabeth J Rossin & Aylwin C Y Ng & International Schizophrenia Consortium & Shaun M Purcell & Pamela Sklar & Edward M Scolnick & Ramnik J Xavier & David Altsh, 2009. "Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.
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