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Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

Author

Listed:
  • Alexandra Zhernakova
  • Eli A Stahl
  • Gosia Trynka
  • Soumya Raychaudhuri
  • Eleanora A Festen
  • Lude Franke
  • Harm-Jan Westra
  • Rudolf S N Fehrmann
  • Fina A S Kurreeman
  • Brian Thomson
  • Namrata Gupta
  • Jihane Romanos
  • Ross McManus
  • Anthony W Ryan
  • Graham Turner
  • Elisabeth Brouwer
  • Marcel D Posthumus
  • Elaine F Remmers
  • Francesca Tucci
  • Rene Toes
  • Elvira Grandone
  • Maria Cristina Mazzilli
  • Anna Rybak
  • Bozena Cukrowska
  • Marieke J H Coenen
  • Timothy R D J Radstake
  • Piet L C M van Riel
  • Yonghong Li
  • Paul I W de Bakker
  • Peter K Gregersen
  • Jane Worthington
  • Katherine A Siminovitch
  • Lars Klareskog
  • Tom W J Huizinga
  • Cisca Wijmenga
  • Robert M Plenge

Abstract

Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-HLA CD and RA risk loci (out of 26 loci for each disease) are shared between both diseases. We hypothesized that there are additional shared risk alleles and that combining genome-wide association study (GWAS) data from each disease would increase power to identify these shared risk alleles. We performed a meta-analysis of two published GWAS on CD (4,533 cases and 10,750 controls) and RA (5,539 cases and 17,231 controls). After genotyping the top associated SNPs in 2,169 CD cases and 2,255 controls, and 2,845 RA cases and 4,944 controls, 8 additional SNPs demonstrated P

Suggested Citation

  • Alexandra Zhernakova & Eli A Stahl & Gosia Trynka & Soumya Raychaudhuri & Eleanora A Festen & Lude Franke & Harm-Jan Westra & Rudolf S N Fehrmann & Fina A S Kurreeman & Brian Thomson & Namrata Gupta &, 2011. "Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci," PLOS Genetics, Public Library of Science, vol. 7(2), pages 1-13, February.
    • Handle: RePEc:plo:pgen00:1002004
    DOI: 10.1371/journal.pgen.1002004
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    References listed on IDEAS

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    1. Soumya Raychaudhuri & Robert M Plenge & Elizabeth J Rossin & Aylwin C Y Ng & International Schizophrenia Consortium & Shaun M Purcell & Pamela Sklar & Edward M Scolnick & Ramnik J Xavier & David Altsh, 2009. "Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.
    2. Andreas Hutloff & Anna M. Dittrich & Katja C. Beier & Barbara Eljaschewitsch & Regine Kraft & Ionnis Anagnostopoulos & Richard A. Kroczek, 1999. "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28," Nature, Nature, vol. 397(6716), pages 263-266, January.
    3. Andreas Hutloff & Anna M. Dittrich & Katja C. Beier & Barbara Eljaschewitsch & Regine Kraft & Ionnis Anagnostopoulos & Richard A. Kroczek, 1999. "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28," Nature, Nature, vol. 402(6763), pages 21-24, December.
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    Cited by:

    1. Hirofumi Nakaoka & Tailin Cui & Atsushi Tajima & Akira Oka & Shigeki Mitsunaga & Koichi Kashiwase & Yasuhiko Homma & Shinji Sato & Yasuo Suzuki & Hidetoshi Inoko & Ituro Inoue, 2011. "A Systems Genetics Approach Provides a Bridge from Discovered Genetic Variants to Biological Pathways in Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-16, September.
    2. Lina-Marcela Diaz-Gallo & Elena Sánchez & Norberto Ortego-Centeno & Jose Mario Sabio & Francisco J García-Hernández & Enrique de Ramón & Miguel A González-Gay & Torsten Witte & Hans-Joachim Anders & M, 2013. "Evidence of New Risk Genetic Factor to Systemic Lupus Erythematosus: The UBASH3A Gene," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-5, April.

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