IDEAS home Printed from https://ideas.repec.org/a/plo/pbio00/3001275.html
   My bibliography  Save this article

Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain

Author

Listed:
  • Alexander J Barnett
  • Walter Reilly
  • Halle R Dimsdale-Zucker
  • Eda Mizrak
  • Zachariah Reagh
  • Charan Ranganath

Abstract

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified the networks that interact with the hippocampus—the default mode network (DMN) and a “medial temporal network” (MTN) that included regions in the medial temporal lobe (MTL) and precuneus. We observed that the MTN plays a critical role in connecting the visual network to the DMN and hippocampus. The DMN could be further divided into 3 subnetworks: a “posterior medial” (PM) subnetwork comprised of posterior cingulate and lateral parietal cortices; an “anterior temporal” (AT) subnetwork comprised of regions in the temporopolar and dorsomedial prefrontal cortex; and a “medial prefrontal” (MP) subnetwork comprised of regions primarily in the medial prefrontal cortex (mPFC). These networks vary in their functional connectivity (FC) along the hippocampal long axis and represent different kinds of information during memory-guided decision-making. Finally, a Neurosynth meta-analysis of fMRI studies suggests new hypotheses regarding the functions of the MTN and DMN subnetworks, providing a framework to guide future research on the neural architecture of episodic memory.Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. This study uses network analyses of intrinsic brain networks at rest to identify and characterize brain networks that interact with the hippocampus and have distinct functions during memory-guided decision making.

Suggested Citation

  • Alexander J Barnett & Walter Reilly & Halle R Dimsdale-Zucker & Eda Mizrak & Zachariah Reagh & Charan Ranganath, 2021. "Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain," PLOS Biology, Public Library of Science, vol. 19(6), pages 1-34, June.
  • Handle: RePEc:plo:pbio00:3001275
    DOI: 10.1371/journal.pbio.3001275
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001275
    Download Restriction: no

    File URL: https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001275&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pbio.3001275?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
    2. Michael A. Ferguson & Chun Lim & Danielle Cooke & R. Ryan Darby & Ona Wu & Natalia S. Rost & Maurizio Corbetta & Jordan Grafman & Michael D. Fox, 2019. "A human memory circuit derived from brain lesions causing amnesia," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    3. Jacob W. Vogel & Renaud La Joie & Michel J. Grothe & Alexandr Diaz-Papkovich & Andrew Doyle & Etienne Vachon-Presseau & Claude Lepage & Reinder Vos de Wael & Rhalena A. Thomas & Yasser Iturria-Medina , 2020. "A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    4. Mathieu Jacomy & Tommaso Venturini & Sebastien Heymann & Mathieu Bastian, 2014. "ForceAtlas2, a Continuous Graph Layout Algorithm for Handy Network Visualization Designed for the Gephi Software," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-12, June.
    5. Maxwell A. Bertolero & B. T. Thomas Yeo & Danielle S. Bassett & Mark D’Esposito, 2018. "A mechanistic model of connector hubs, modularity and cognition," Nature Human Behaviour, Nature, vol. 2(10), pages 765-777, October.
    6. Hamed Nili & Cai Wingfield & Alexander Walther & Li Su & William Marslen-Wilson & Nikolaus Kriegeskorte, 2014. "A Toolbox for Representational Similarity Analysis," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-11, April.
    7. Marika C Inhoff & Laura A Libby & Takao Noguchi & Bradley C Love & Charan Ranganath, 2018. "Dynamic integration of conceptual information during learning," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-26, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Benjamin Lahner & Kshitij Dwivedi & Polina Iamshchinina & Monika Graumann & Alex Lascelles & Gemma Roig & Alessandro Thomas Gifford & Bowen Pan & SouYoung Jin & N. Apurva Ratan Murty & Kendrick Kay & , 2024. "Modeling short visual events through the BOLD moments video fMRI dataset and metadata," Nature Communications, Nature, vol. 15(1), pages 1-26, December.
    2. Valentina Krenz & Arjen Alink & Tobias Sommer & Benno Roozendaal & Lars Schwabe, 2023. "Time-dependent memory transformation in hippocampus and neocortex is semantic in nature," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Duan, Zhengxiao & Zhang, Yanni & Deng, Jun & Shu, Pan & Yao, Di, 2023. "A systematic exploration of mapping knowledge domains for free radical research related to coal," Energy, Elsevier, vol. 282(C).
    4. Gong, Chen & Tang, Pan & Wang, Yutong, 2019. "Measuring the network connectedness of global stock markets," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 535(C).
    5. Satoko Amemori & Ann M. Graybiel & Ken-ichi Amemori, 2024. "Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Julia Berezutskaya & Zachary V Freudenburg & Umut Güçlü & Marcel A J van Gerven & Nick F Ramsey, 2020. "Brain-optimized extraction of complex sound features that drive continuous auditory perception," PLOS Computational Biology, Public Library of Science, vol. 16(7), pages 1-34, July.
    7. Leon D. Lotter & Amin Saberi & Justine Y. Hansen & Bratislav Misic & Casey Paquola & Gareth J. Barker & Arun L. W. Bokde & Sylvane Desrivières & Herta Flor & Antoine Grigis & Hugh Garavan & Penny Gowl, 2024. "Regional patterns of human cortex development correlate with underlying neurobiology," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    8. Gomez-Gonzalez, Jose E. & Hirs-Garzón, Jorge & Sanín-Restrepo, Sebastián, 2021. "Dynamic relations between oil and stock markets: Volatility spillovers, networks and causality," International Economics, Elsevier, vol. 165(C), pages 37-50.
    9. Haewon Nam & Chongwon Pae & Jinseok Eo & Maeng-Keun Oh & Hae-Jeong Park, 2021. "Inter-species cortical registration between macaques and humans using a functional network property under a spherical demons framework," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-22, October.
    10. Jessica Dafflon & Pedro F. Da Costa & František Váša & Ricardo Pio Monti & Danilo Bzdok & Peter J. Hellyer & Federico Turkheimer & Jonathan Smallwood & Emily Jones & Robert Leech, 2022. "A guided multiverse study of neuroimaging analyses," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    11. Florentin Gloetzl & Ernest Aigner, 2015. "Pluralism in the Market of Science? A citation network analysis of economic research at universities in Vienna," Ecological Economics Papers ieep5, Institute of Ecological Economics.
    12. Martin, Drew & Palakshappa, Nitha & Woodside, Arch, 2019. "Consumer metaphoria: Uncovering the automaticity of animal, product/brand, and country meanings," Australasian marketing journal, Elsevier, vol. 27(2), pages 113-125.
    13. Kamil Yilmaz, 2018. "Bank Volatility Connectedness in South East Asia," Koç University-TUSIAD Economic Research Forum Working Papers 1807, Koc University-TUSIAD Economic Research Forum.
    14. Costantini, Mauro & Maaitah, Ahmad & Mishra, Tapas & Sousa, Ricardo M., 2023. "Bitcoin market networks and cyberattacks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 630(C).
    15. Daria E. A. Jensen & Klaus P. Ebmeier & Sana Suri & Matthew F. S. Rushworth & Miriam C. Klein-Flügge, 2024. "Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    16. Arno Klein & Satrajit S Ghosh & Forrest S Bao & Joachim Giard & Yrjö Häme & Eliezer Stavsky & Noah Lee & Brian Rossa & Martin Reuter & Elias Chaibub Neto & Anisha Keshavan, 2017. "Mindboggling morphometry of human brains," PLOS Computational Biology, Public Library of Science, vol. 13(2), pages 1-40, February.
    17. Manoj Kumar & Cameron T Ellis & Qihong Lu & Hejia Zhang & Mihai Capotă & Theodore L Willke & Peter J Ramadge & Nicholas B Turk-Browne & Kenneth A Norman, 2020. "BrainIAK tutorials: User-friendly learning materials for advanced fMRI analysis," PLOS Computational Biology, Public Library of Science, vol. 16(1), pages 1-12, January.
    18. Nassar S. Al-Nassar & Abdulrahman A. Albahouth, 2023. "Inflation Spillovers among Advanced and Emerging Economies: Evidence from the G20 Group," Economies, MDPI, vol. 11(4), pages 1-25, April.
    19. Ann Hillier & Ryan P Kelly & Terrie Klinger, 2016. "Narrative Style Influences Citation Frequency in Climate Change Science," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-12, December.
    20. Nicola Melluso & Andrea Bonaccorsi & Filippo Chiarello & Gualtiero Fantoni, 2021. "Rapid detection of fast innovation under the pressure of COVID-19," Papers 2102.00197, arXiv.org.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pbio00:3001275. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosbiology (email available below). General contact details of provider: https://journals.plos.org/plosbiology/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.