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A human memory circuit derived from brain lesions causing amnesia

Author

Listed:
  • Michael A. Ferguson

    (Beth Israel Deaconess Medical Center
    Harvard Medical School)

  • Chun Lim

    (Beth Israel Deaconess Medical Center
    Harvard Medical School)

  • Danielle Cooke

    (Beth Israel Deaconess Medical Center
    Harvard Medical School)

  • R. Ryan Darby

    (Vanderbilt University Medical Center)

  • Ona Wu

    (Massachusetts General Hospital)

  • Natalia S. Rost

    (Massachusetts General Hospital)

  • Maurizio Corbetta

    (Università di Padova
    Washington University, School of Medicine
    Università di Padova)

  • Jordan Grafman

    (Shirley Ryan Ability Lab
    Northwestern University)

  • Michael D. Fox

    (Beth Israel Deaconess Medical Center
    Harvard Medical School
    Massachusetts General Hospital)

Abstract

Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer’s disease, and brain stimulation sites reported to enhance memory in humans.

Suggested Citation

  • Michael A. Ferguson & Chun Lim & Danielle Cooke & R. Ryan Darby & Ona Wu & Natalia S. Rost & Maurizio Corbetta & Jordan Grafman & Michael D. Fox, 2019. "A human memory circuit derived from brain lesions causing amnesia," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11353-z
    DOI: 10.1038/s41467-019-11353-z
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    Cited by:

    1. Alexander J Barnett & Walter Reilly & Halle R Dimsdale-Zucker & Eda Mizrak & Zachariah Reagh & Charan Ranganath, 2021. "Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain," PLOS Biology, Public Library of Science, vol. 19(6), pages 1-34, June.

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