The role of inferior frontal junction in controlling the spatially global effect of feature-based attention in human visual areas

Feature-based attention has a spatially global effect, i.e., responses to stimuli that share features with an attended stimulus are enhanced not only at the attended location but throughout the visual field. However, how feature-based attention modulates cortical neural responses at unattended locations remains unclear. Here we used functional magnetic resonance imaging (fMRI) to examine this issue as human participants performed motion- (Experiment 1) and color- (Experiment 2) based attention tasks. Results indicated that, in both experiments, the respective visual processing areas (middle temporal area [MT+] for motion and V4 for color) as well as early visual, parietal, and prefrontal areas all showed the classic feature-based attention effect, with neural responses to the unattended stimulus significantly elevated when it shared the same feature with the attended stimulus. Effective connectivity analysis using dynamic causal modeling (DCM) showed that this spatially global effect in the respective visual processing areas (MT+ for motion and V4 for color), intraparietal sulcus (IPS), frontal eye field (FEF), medial frontal gyrus (mFG), and primary visual cortex (V1) was derived by feedback from the inferior frontal junction (IFJ). Complementary effective connectivity analysis using Granger causality modeling (GCM) confirmed that, in both experiments, the node with the highest outflow and netflow degree was IFJ, which was thus considered to be the source of the network. These results indicate a source for the spatially global effect of feature-based attention in the human prefrontal cortex.Author summary: Attentional selection is the mechanism by which relevant sensory information is processed preferentially. Feature-based attention plays a key role in identifying an attentional target in a complex scene, because we often know the features of the target but not its exact location. The ability to quickly select the target is mainly attributed to enhancement of responses to stimuli that share features with an attended stimulus, not only at the attended location but throughout the whole visual field. However, little is known regarding how feature-based attention modulates brain responses at unattended locations. Here we used fMRI and advanced connectivity analyses to examine human subjects as they performed either motion- or color-based attention tasks. Our results indicated that the visual processing areas for motion and color showed the feature-based attention effect. Effective connectivity analysis showed that this feature-based attention effect was derived by feedback from the inferior frontal junction, an area of the posterior lateral prefrontal cortex involved in many different cognitive processes, including spatial attention and working memory. Further modeling confirmed that the inferior frontal junction showed connectivity features supporting its role as the source of the network. Our results support the hypothesis that the inferior frontal junction plays a key role in the spatially global effect of feature-based attention.