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Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies

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  • Kimberley E Wever
  • Carlijn R Hooijmans
  • Niels P Riksen
  • Thomas B Sterenborg
  • Emily S Sena
  • Merel Ritskes-Hoitinga
  • Michiel C Warlé

Abstract

Background: Ischemic preconditioning (IPC) of the heart is a protective strategy in which a brief ischemic stimulus immediately before a lethal ischemic episode potently limits infarct size. Although very promising in animal models of myocardial infarction, IPC has not yet been successfully translated to benefit for patients. Objective: To appraise all preclinical evidence on IPC for myocardial infarction and identify factors hampering translation. Methods and results: Using systematic review and meta-analysis, we identified 503 animal studies reporting infarct size data from 785 comparisons between IPC-treated and control animals. Overall, IPC reduced myocardial infarction by 24.6% [95%CI 23.5, 25.6]. Subgroup analysis showed that IPC efficacy was reduced in comorbid animals and non-rodents. Efficacy was highest in studies using 2–3 IPC cycles applied

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  • Kimberley E Wever & Carlijn R Hooijmans & Niels P Riksen & Thomas B Sterenborg & Emily S Sena & Merel Ritskes-Hoitinga & Michiel C Warlé, 2015. "Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0142021
    DOI: 10.1371/journal.pone.0142021
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    References listed on IDEAS

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    1. H Bart van der Worp & David W Howells & Emily S Sena & Michelle J Porritt & Sarah Rewell & Victoria O'Collins & Malcolm R Macleod, 2010. "Can Animal Models of Disease Reliably Inform Human Studies?," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-8, March.
    2. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    3. Jennifer A Hirst & Jeremy Howick & Jeffrey K Aronson & Nia Roberts & Rafael Perera & Constantinos Koshiaris & Carl Heneghan, 2014. "The Need for Randomization in Animal Trials: An Overview of Systematic Reviews," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-11, June.
    4. Kimberley E Wever & Theo P Menting & Maroeska Rovers & J Adam van der Vliet & Gerard A Rongen & Rosalinde Masereeuw & Merel Ritskes-Hoitinga & Carlijn R Hooijmans & Michiel Warlé, 2012. "Ischemic Preconditioning in the Animal Kidney, a Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-10, February.
    5. Carol Kilkenny & William J Browne & Innes C Cuthill & Michael Emerson & Douglas G Altman, 2010. "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research," PLOS Biology, Public Library of Science, vol. 8(6), pages 1-5, June.
    6. Colin D Mathers & Dejan Loncar, 2006. "Projections of Global Mortality and Burden of Disease from 2002 to 2030," PLOS Medicine, Public Library of Science, vol. 3(11), pages 1-20, November.
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    1. Nienke A Hesen & Niels P Riksen & Bart Aalders & Merel Ritskes-Hoitinga & Saloua El Messaoudi & Kimberley E Wever, 2017. "A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-18, August.

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