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Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies

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  • David Baker
  • Katie Lidster
  • Ana Sottomayor
  • Sandra Amor

Abstract

: A study by David Baker and colleagues reveals poor quality of reporting in pre-clinical animal research and a failure of journals to implement the ARRIVE guidelines. There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease. In 2010, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were introduced to help improve reporting standards. They were published in PLOS Biology and endorsed by funding agencies and publishers and their journals, including PLOS, Nature research journals, and other top-tier journals. Yet our analysis of papers published in PLOS and Nature journals indicates that there has been very little improvement in reporting standards since then. This suggests that authors, referees, and editors generally are ignoring guidelines, and the editorial endorsement is yet to be effectively implemented.

Suggested Citation

  • David Baker & Katie Lidster & Ana Sottomayor & Sandra Amor, 2014. "Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies," PLOS Biology, Public Library of Science, vol. 12(1), pages 1-6, January.
    • Handle: RePEc:plo:pbio00:1001756
    DOI: 10.1371/journal.pbio.1001756
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    References listed on IDEAS

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    1. Beverly S Muhlhausler & Frank H Bloomfield & Matthew W Gillman, 2013. "Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials," PLOS Biology, Public Library of Science, vol. 11(2), pages 1-6, February.
    2. Patrizio E Tressoldi & David Giofré & Francesco Sella & Geoff Cumming, 2013. "High Impact = High Statistical Standards? Not Necessarily So," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
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    4. Emily S Sena & H Bart van der Worp & Philip M W Bath & David W Howells & Malcolm R Macleod, 2010. "Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy," PLOS Biology, Public Library of Science, vol. 8(3), pages 1-8, March.
    5. Carol Kilkenny & William J Browne & Innes C Cuthill & Michael Emerson & Douglas G Altman, 2010. "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research," PLOS Biology, Public Library of Science, vol. 8(6), pages 1-5, June.
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    Cited by:

    1. Dean A Fergusson & Marc T Avey & Carly C Barron & Mathew Bocock & Kristen E Biefer & Sylvain Boet & Stephane L Bourque & Isidora Conic & Kai Chen & Yuan Yi Dong & Grace M Fox & Ronald B George & Neil , 2019. "Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-15, May.
    2. Natasha A Karp & Terry F Meehan & Hugh Morgan & Jeremy C Mason & Andrew Blake & Natalja Kurbatova & Damian Smedley & Julius Jacobsen & Richard F Mott & Vivek Iyer & Peter Matthews & David G Melvin & S, 2015. "Applying the ARRIVE Guidelines to an In Vivo Database," PLOS Biology, Public Library of Science, vol. 13(5), pages 1-11, May.
    3. Fala Cramond & Cadi Irvine & Jing Liao & David Howells & Emily Sena & Gillian Currie & Malcolm Macleod, 2016. "Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals’ editorial policy for life sciences research on the completeness of reporting study design and execut," Scientometrics, Springer;Akadémiai Kiadó, vol. 108(1), pages 315-328, July.
    4. Pandora Pound & Christine J Nicol, 2018. "Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-26, March.
    5. Leonard P Freedman & Iain M Cockburn & Timothy S Simcoe, 2015. "The Economics of Reproducibility in Preclinical Research," PLOS Biology, Public Library of Science, vol. 13(6), pages 1-9, June.
    6. Marc T Avey & David Moher & Katrina J Sullivan & Dean Fergusson & Gilly Griffin & Jeremy M Grimshaw & Brian Hutton & Manoj M Lalu & Malcolm Macleod & John Marshall & Shirley H J Mei & Michael Rudnicki, 2016. "The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-13, November.
    7. Gail F Davies & Beth J Greenhough & Pru Hobson-West & Robert G W Kirk & Ken Applebee & Laura C Bellingan & Manuel Berdoy & Henry Buller & Helen J Cassaday & Keith Davies & Daniela Diefenbacher & Tone , 2016. "Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-12, July.
    8. SeungHye Han & Tolani F Olonisakin & John P Pribis & Jill Zupetic & Joo Heung Yoon & Kyle M Holleran & Kwonho Jeong & Nader Shaikh & Doris M Rubio & Janet S Lee, 2017. "A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-14, September.
    9. Tracey L Weissgerber & Natasa M Milic & Stacey J Winham & Vesna D Garovic, 2015. "Beyond Bar and Line Graphs: Time for a New Data Presentation Paradigm," PLOS Biology, Public Library of Science, vol. 13(4), pages 1-10, April.
    10. Vivian Leung & Frédérik Rousseau-Blass & Guy Beauchamp & Daniel S J Pang, 2018. "ARRIVE has not ARRIVEd: Support for the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines does not improve the reporting quality of papers in animal welfare, analgesia or anesthesi," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-13, May.
    11. Malcolm R Macleod & Aaron Lawson McLean & Aikaterini Kyriakopoulou & Stylianos Serghiou & Arno de Wilde & Nicki Sherratt & Theo Hirst & Rachel Hemblade & Zsanett Bahor & Cristina Nunes-Fonseca & Aparn, 2015. "Risk of Bias in Reports of In Vivo Research: A Focus for Improvement," PLOS Biology, Public Library of Science, vol. 13(10), pages 1-12, October.
    12. Tracey L Weissgerber & Vesna D Garovic & Jelena S Milin-Lazovic & Stacey J Winham & Zoran Obradovic & Jerome P Trzeciakowski & Natasa M Milic, 2016. "Reinventing Biostatistics Education for Basic Scientists," PLOS Biology, Public Library of Science, vol. 14(4), pages 1-12, April.

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