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Semiparametric group testing regression models

Author

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  • D. Wang
  • C. S. McMahan
  • C. M. Gallagher
  • K. B. Kulasekera

Abstract

Group testing, through the use of pooling, has proven to be an efficient method of reducing the time and cost associated with screening for a binary characteristic of interest, such as infection status. A topic of key interest in the statistical literature involves the development of regression models that relate individual-level covariates to testing responses observed from pooled specimens. In this article, we propose a general semiparametric framework that allows for the inclusion of multi-dimensional covariates, decoding information, and imperfect testing. The asymptotic properties of our estimators are presented and guidance on finite sample implementation is provided. We illustrate the performance of our methods through simulation and by applying them to chlamydia and gonorrhea data collected by the Nebraska Public Health Laboratory as a part of the Infertility Prevention Project.

Suggested Citation

  • D. Wang & C. S. McMahan & C. M. Gallagher & K. B. Kulasekera, 2014. "Semiparametric group testing regression models," Biometrika, Biometrika Trust, vol. 101(3), pages 587-598.
    • Handle: RePEc:oup:biomet:v:101:y:2014:i:3:p:587-598.
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    References listed on IDEAS

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    Cited by:

    1. Xinlei Zuo & Juan Ding & Junjian Zhang & Wenjun Xiong, 2024. "Nonparametric Additive Regression for High-Dimensional Group Testing Data," Mathematics, MDPI, vol. 12(5), pages 1-21, February.
    2. Md S. Warasi & Laura L. Hungerford & Kevin Lahmers, 2022. "Optimizing Pooled Testing for Estimating the Prevalence of Multiple Diseases," Journal of Agricultural, Biological and Environmental Statistics, Springer;The International Biometric Society;American Statistical Association, vol. 27(4), pages 713-727, December.
    3. Chase N. Joyner & Christopher S. McMahan & Joshua M. Tebbs & Christopher R. Bilder, 2020. "From mixed effects modeling to spike and slab variable selection: A Bayesian regression model for group testing data," Biometrics, The International Biometric Society, vol. 76(3), pages 913-923, September.
    4. Xianzheng Huang & Md Shamim Sarker Warasi, 2017. "Maximum Likelihood Estimators in Regression Models for Error-prone Group Testing Data," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 44(4), pages 918-931, December.
    5. Karl B. Gregory & Dewei Wang & Christopher S. McMahan, 2019. "Adaptive elastic net for group testing," Biometrics, The International Biometric Society, vol. 75(1), pages 13-23, March.

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