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Modular assembly of the nucleolar pre-60S ribosomal subunit

Author

Listed:
  • Zahra Assur Sanghai

    (Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University)

  • Linamarie Miller

    (Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University
    Tri-Institutional Training Program in Chemical Biology, The Rockefeller University)

  • Kelly R. Molloy

    (Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University)

  • Jonas Barandun

    (Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University)

  • Mirjam Hunziker

    (Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University)

  • Malik Chaker-Margot

    (Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University
    Tri-Institutional Training Program in Chemical Biology, The Rockefeller University)

  • Junjie Wang

    (Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University)

  • Brian T. Chait

    (Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University)

  • Sebastian Klinge

    (Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University)

Abstract

Cryo-electron microscopy structures of multiple states along the assembly pathway of the nucleolar pre-60S ribosomal subunit suggest that folding of the pre-ribosomal RNA and sequential binding of transient assembly factors are regulated by steric hindrance among these factors.

Suggested Citation

  • Zahra Assur Sanghai & Linamarie Miller & Kelly R. Molloy & Jonas Barandun & Mirjam Hunziker & Malik Chaker-Margot & Junjie Wang & Brian T. Chait & Sebastian Klinge, 2018. "Modular assembly of the nucleolar pre-60S ribosomal subunit," Nature, Nature, vol. 556(7699), pages 126-129, April.
    • Handle: RePEc:nat:nature:v:556:y:2018:i:7699:d:10.1038_nature26156
    DOI: 10.1038/nature26156
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    Citations

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    Cited by:

    1. Bo Qin & Simon M. Lauer & Annika Balke & Carlos H. Vieira-Vieira & Jörg Bürger & Thorsten Mielke & Matthias Selbach & Patrick Scheerer & Christian M. T. Spahn & Rainer Nikolay, 2023. "Cryo-EM captures early ribosome assembly in action," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Victor E. Cruz & Christine S. Weirich & Nagesh Peddada & Jan P. Erzberger, 2024. "The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Gerald Ryan R. Aquino & Philipp Hackert & Nicolai Krogh & Kuan-Ting Pan & Mariam Jaafar & Anthony K. Henras & Henrik Nielsen & Henning Urlaub & Katherine E. Bohnsack & Markus T. Bohnsack, 2021. "The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    4. Kai Sheng & Ning Li & Jessica N. Rabuck-Gibbons & Xiyu Dong & Dmitry Lyumkis & James R. Williamson, 2023. "Assembly landscape for the bacterial large ribosomal subunit," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Lisa Kofler & Lorenz Grundmann & Magdalena Gerhalter & Michael Prattes & Juliane Merl-Pham & Gertrude Zisser & Irina Grishkovskaya & Victor-Valentin Hodirnau & Martin Vareka & Rolf Breinbauer & Stefan, 2024. "The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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