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Effector CD8 T cells dedifferentiate into long-lived memory cells

Author

Listed:
  • Ben Youngblood

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine
    St. Jude Children’s Research Hospital)

  • J. Scott Hale

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Haydn T. Kissick

    (Emory University School of Medicine)

  • Eunseon Ahn

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Xiaojin Xu

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Andreas Wieland

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Koichi Araki

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Erin E. West

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Hazem E. Ghoneim

    (St. Jude Children’s Research Hospital)

  • Yiping Fan

    (St. Jude Children’s Research Hospital)

  • Pranay Dogra

    (St. Jude Children’s Research Hospital)

  • Carl W. Davis

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Bogumila T. Konieczny

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Rustom Antia

    (Emory University)

  • Xiaodong Cheng

    (Emory University School of Medicine
    The University of Texas MD Anderson Cancer Center)

  • Rafi Ahmed

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

Abstract

DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

Suggested Citation

  • Ben Youngblood & J. Scott Hale & Haydn T. Kissick & Eunseon Ahn & Xiaojin Xu & Andreas Wieland & Koichi Araki & Erin E. West & Hazem E. Ghoneim & Yiping Fan & Pranay Dogra & Carl W. Davis & Bogumila T, 2017. "Effector CD8 T cells dedifferentiate into long-lived memory cells," Nature, Nature, vol. 552(7685), pages 404-409, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7685:d:10.1038_nature25144
    DOI: 10.1038/nature25144
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    Citations

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    Cited by:

    1. Shu Shien Chin & Erik Guillen & Laurent Chorro & Sooraj Achar & Karina Ng & Susanne Oberle & Francesca Alfei & Dietmar Zehn & Grégoire Altan-Bonnet & Fabien Delahaye & Grégoire Lauvau, 2022. "T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Xiaofeng Liao & Wenxue Li & Hongyue Zhou & Barani Kumar Rajendran & Ao Li & Jingjing Ren & Yi Luan & David A. Calderwood & Benjamin Turk & Wenwen Tang & Yansheng Liu & Dianqing Wu, 2024. "The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Kaifan Bao & Xiaoqun Gu & Yajun Song & Yijing Zhou & Yanyan Chen & Xi Yu & Weiyuan Yuan & Liyun Shi & Jie Zheng & Min Hong, 2024. "TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Leticia Laura Niborski & Paul Gueguen & Mengliang Ye & Allan Thiolat & Rodrigo Nalio Ramos & Pamela Caudana & Jordan Denizeau & Ludovic Colombeau & Raphaël Rodriguez & Christel Goudot & Jean-Michel Lu, 2022. "CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Joshua S. Woodworth & Vanessa Contreras & Dennis Christensen & Thibaut Naninck & Nidhal Kahlaoui & Anne-Sophie Gallouët & Sébastien Langlois & Emma Burban & Candie Joly & Wesley Gros & Nathalie Dereud, 2024. "MINCLE and TLR9 agonists synergize to induce Th1/Th17 vaccine memory and mucosal recall in mice and non-human primates," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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