IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v552y2017i7685d10.1038_nature25144.html
   My bibliography  Save this article

Effector CD8 T cells dedifferentiate into long-lived memory cells

Author

Listed:
  • Ben Youngblood

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine
    St. Jude Children’s Research Hospital)

  • J. Scott Hale

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Haydn T. Kissick

    (Emory University School of Medicine)

  • Eunseon Ahn

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Xiaojin Xu

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Andreas Wieland

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Koichi Araki

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Erin E. West

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Hazem E. Ghoneim

    (St. Jude Children’s Research Hospital)

  • Yiping Fan

    (St. Jude Children’s Research Hospital)

  • Pranay Dogra

    (St. Jude Children’s Research Hospital)

  • Carl W. Davis

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Bogumila T. Konieczny

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

  • Rustom Antia

    (Emory University)

  • Xiaodong Cheng

    (Emory University School of Medicine
    The University of Texas MD Anderson Cancer Center)

  • Rafi Ahmed

    (Emory Vaccine Center, Emory University School of Medicine
    Emory University School of Medicine)

Abstract

DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

Suggested Citation

  • Ben Youngblood & J. Scott Hale & Haydn T. Kissick & Eunseon Ahn & Xiaojin Xu & Andreas Wieland & Koichi Araki & Erin E. West & Hazem E. Ghoneim & Yiping Fan & Pranay Dogra & Carl W. Davis & Bogumila T, 2017. "Effector CD8 T cells dedifferentiate into long-lived memory cells," Nature, Nature, vol. 552(7685), pages 404-409, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7685:d:10.1038_nature25144
    DOI: 10.1038/nature25144
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25144
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25144?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shu Shien Chin & Erik Guillen & Laurent Chorro & Sooraj Achar & Karina Ng & Susanne Oberle & Francesca Alfei & Dietmar Zehn & Grégoire Altan-Bonnet & Fabien Delahaye & Grégoire Lauvau, 2022. "T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Xiaofeng Liao & Wenxue Li & Hongyue Zhou & Barani Kumar Rajendran & Ao Li & Jingjing Ren & Yi Luan & David A. Calderwood & Benjamin Turk & Wenwen Tang & Yansheng Liu & Dianqing Wu, 2024. "The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Leticia Laura Niborski & Paul Gueguen & Mengliang Ye & Allan Thiolat & Rodrigo Nalio Ramos & Pamela Caudana & Jordan Denizeau & Ludovic Colombeau & Raphaël Rodriguez & Christel Goudot & Jean-Michel Lu, 2022. "CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:552:y:2017:i:7685:d:10.1038_nature25144. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.