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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Author

Listed:
  • Vasanthi S. Viswanathan

    (Broad Institute)

  • Matthew J. Ryan

    (Broad Institute)

  • Harshil D. Dhruv

    (The Translational Genomics Research Institute)

  • Shubhroz Gill

    (Broad Institute)

  • Ossia M. Eichhoff

    (University of Zurich)

  • Brinton Seashore-Ludlow

    (Broad Institute)

  • Samuel D. Kaffenberger

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • John K. Eaton

    (Broad Institute)

  • Kenichi Shimada

    (Laboratory of Systems Pharmacology, Harvard Medical School)

  • Andrew J. Aguirre

    (Broad Institute
    Dana Farber Cancer Institute)

  • Srinivas R. Viswanathan

    (Broad Institute
    Dana Farber Cancer Institute)

  • Shrikanta Chattopadhyay

    (Broad Institute)

  • Pablo Tamayo

    (Broad Institute
    School of Medicine, University of California San Diego)

  • Wan Seok Yang

    (St. John’s University)

  • Matthew G. Rees

    (Broad Institute)

  • Sixun Chen

    (Broad Institute)

  • Zarko V. Boskovic

    (Broad Institute)

  • Sarah Javaid

    (Massachusetts General Hospital Cancer Center)

  • Cherrie Huang

    (Broad Institute)

  • Xiaoyun Wu

    (Broad Institute)

  • Yuen-Yi Tseng

    (Broad Institute)

  • Elisabeth M. Roider

    (University of Zurich)

  • Dong Gao

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • James M. Cleary

    (Dana Farber Cancer Institute)

  • Brian M. Wolpin

    (Dana Farber Cancer Institute)

  • Jill P. Mesirov

    (Broad Institute
    School of Medicine, University of California San Diego)

  • Daniel A. Haber

    (Massachusetts General Hospital Cancer Center
    Howard Hughes Medical Institute)

  • Jeffrey A. Engelman

    (Oncology Disease Area, Novartis Institute for Biomedical Research)

  • Jesse S. Boehm

    (Broad Institute)

  • Joanne D. Kotz

    (Broad Institute)

  • Cindy S. Hon

    (Broad Institute)

  • Yu Chen

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • William C. Hahn

    (Broad Institute
    Dana Farber Cancer Institute)

  • Mitchell P. Levesque

    (University of Zurich)

  • John G. Doench

    (Broad Institute)

  • Michael E. Berens

    (The Translational Genomics Research Institute)

  • Alykhan F. Shamji

    (Broad Institute)

  • Paul A. Clemons

    (Broad Institute)

  • Brent R. Stockwell

    (Columbia University)

  • Stuart L. Schreiber

    (Broad Institute
    Howard Hughes Medical Institute
    Harvard University)

Abstract

Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.

Suggested Citation

  • Vasanthi S. Viswanathan & Matthew J. Ryan & Harshil D. Dhruv & Shubhroz Gill & Ossia M. Eichhoff & Brinton Seashore-Ludlow & Samuel D. Kaffenberger & John K. Eaton & Kenichi Shimada & Andrew J. Aguirr, 2017. "Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway," Nature, Nature, vol. 547(7664), pages 453-457, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7664:d:10.1038_nature23007
    DOI: 10.1038/nature23007
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    Citations

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    Cited by:

    1. Jun Jiang & Lili Yang & Qianqian Xie & Xi Liu & Jie Jiang & Jie Zhang & Shuping Zhang & Huizhen Zheng & Wenjie Li & Xiaoming Cai & Sijin Liu & Ruibin Li, 2024. "Synthetic vectors for activating the driving axis of ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Heike Chauvistré & Batool Shannan & Sheena M. Daignault-Mill & Robert J. Ju & Daniel Picard & Stefanie Egetemaier & Renáta Váraljai & Christine S. Gibhardt & Antonio Sechi & Farnusch Kaschani & Oliver, 2022. "Persister state-directed transitioning and vulnerability in melanoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Mihee Oh & Seo Young Jang & Ji-Yoon Lee & Jong Woo Kim & Youngae Jung & Jiwoo Kim & Jinho Seo & Tae-Su Han & Eunji Jang & Hye Young Son & Dain Kim & Min Wook Kim & Jin-Sung Park & Kwon-Ho Song & Kyoun, 2023. "The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Dadi Jiang & Youming Guo & Tianyu Wang & Liang Wang & Yuelong Yan & Ling Xia & Rakesh Bam & Zhifen Yang & Hyemin Lee & Takao Iwawaki & Boyi Gan & Albert C. Koong, 2024. "IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Nneka E. Mbah & Amy L. Myers & Peter Sajjakulnukit & Chan Chung & Joyce K. Thompson & Hanna S. Hong & Heather Giza & Derek Dang & Zeribe C. Nwosu & Mengrou Shan & Stefan R. Sweha & Daniella D. Maydan , 2024. "Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    6. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Caterina Bartolacci & Cristina Andreani & Gonçalo Vale & Stefano Berto & Margherita Melegari & Anna Colleen Crouch & Dodge L. Baluya & George Kemble & Kurt Hodges & Jacqueline Starrett & Katerina Poli, 2022. "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    8. Pranavi Koppula & Guang Lei & Yilei Zhang & Yuelong Yan & Chao Mao & Lavanya Kondiparthi & Jiejun Shi & Xiaoguang Liu & Amber Horbath & Molina Das & Wei Li & Masha V. Poyurovsky & Kellen Olszewski & B, 2022. "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Bartosz Wiernicki & Sophia Maschalidi & Jonathan Pinney & Sandy Adjemian & Tom Vanden Berghe & Kodi S. Ravichandran & Peter Vandenabeele, 2022. "Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Jenna E. Leeuwen & Wail Ba-Alawi & Emily Branchard & Jennifer Cruickshank & Wiebke Schormann & Joseph Longo & Jennifer Silvester & Peter L. Gross & David W. Andrews & David W. Cescon & Benjamin Haibe-, 2022. "Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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