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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Author

Listed:
  • Adam G. Larson

    (University of California, San Francisco
    Tetrad Graduate Program, University of California, San Francisco)

  • Daniel Elnatan

    (University of California, San Francisco
    Tetrad Graduate Program, University of California, San Francisco)

  • Madeline M. Keenen

    (University of California, San Francisco
    Tetrad Graduate Program, University of California, San Francisco)

  • Michael J. Trnka

    (University of California, San Francisco)

  • Jonathan B. Johnston

    (University of California, San Francisco)

  • Alma L. Burlingame

    (University of California, San Francisco)

  • David A. Agard

    (University of California, San Francisco
    Howard Hughes Medical Institute, University of California, San Francisco)

  • Sy Redding

    (University of California, San Francisco)

  • Geeta J. Narlikar

    (University of California, San Francisco)

Abstract

Phosphorylation or DNA binding promotes the physical partitioning of HP1α out of a soluble aqueous phase into droplets, suggesting that the repressive action of heterochromatin may in part be mediated by the phase separation of HP1.

Suggested Citation

  • Adam G. Larson & Daniel Elnatan & Madeline M. Keenen & Michael J. Trnka & Jonathan B. Johnston & Alma L. Burlingame & David A. Agard & Sy Redding & Geeta J. Narlikar, 2017. "Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin," Nature, Nature, vol. 547(7662), pages 236-240, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7662:d:10.1038_nature22822
    DOI: 10.1038/nature22822
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    Cited by:

    1. Surya K Ghosh & Daniel Jost, 2018. "How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-26, May.
    2. Ziad Ibrahim & Tao Wang & Olivier Destaing & Nicola Salvi & Naghmeh Hoghoughi & Clovis Chabert & Alexandra Rusu & Jinjun Gao & Leonardo Feletto & Nicolas Reynoird & Thomas Schalch & Yingming Zhao & Ma, 2022. "Structural insights into p300 regulation and acetylation-dependent genome organisation," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    3. Wenqi Sun & Qianhua Dong & Xueqing Li & Jinxin Gao & Xianwen Ye & Chunyi Hu & Fei Li & Yong Chen, 2024. "The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Catherine Naughton & Covadonga Huidobro & Claudia R. Catacchio & Adam Buckle & Graeme R. Grimes & Ryu-Suke Nozawa & Stefania Purgato & Mariano Rocchi & Nick Gilbert, 2022. "Human centromere repositioning activates transcription and opens chromatin fibre structure," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. David E. Torres & H. Martin Kramer & Vittorio Tracanna & Gabriel L. Fiorin & David E. Cook & Michael F. Seidl & Bart P. H. J. Thomma, 2024. "Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Manisha Poudyal & Komal Patel & Laxmikant Gadhe & Ajay Singh Sawner & Pradeep Kadu & Debalina Datta & Semanti Mukherjee & Soumik Ray & Ambuja Navalkar & Siddhartha Maiti & Debdeep Chatterjee & Jyoti D, 2023. "Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    7. Yifeng Qi & Bin Zhang, 2021. "Chromatin network retards nucleoli coalescence," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    8. Khalil Joron & Juliane Oliveira Viegas & Liam Haas-Neill & Sariel Bier & Paz Drori & Shani Dvir & Patrick Siang Lin Lim & Sarah Rauscher & Eran Meshorer & Eitan Lerner, 2023. "Fluorescent protein lifetimes report densities and phases of nuclear condensates during embryonic stem-cell differentiation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Judith H. I. Haarhuis & Robin H. Weide & Vincent A. Blomen & Koen D. Flach & Hans Teunissen & Laureen Willems & Thijn R. Brummelkamp & Benjamin D. Rowland & Elzo Wit, 2022. "A Mediator-cohesin axis controls heterochromatin domain formation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    10. Clara Lopes Novo & Emily V. Wong & Colin Hockings & Chetan Poudel & Eleanor Sheekey & Meike Wiese & Hanneke Okkenhaug & Simon J. Boulton & Srinjan Basu & Simon Walker & Gabriele S. Kaminski Schierle &, 2022. "Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    11. Pan Jia & Xiang Li & Xuelei Wang & Liangjiao Yao & Yingying Xu & Yu Hu & Wenwen Xu & Zhe He & Qifan Zhao & Yicong Deng & Yi Zang & Meiyu Zhang & Yan Zhang & Jun Qin & Wei Lu, 2021. "ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    12. Taehyun Kim & Jaeyoon Yoo & Sungho Do & Dong Soo Hwang & YongKeun Park & Yongdae Shin, 2023. "RNA-mediated demixing transition of low-density condensates," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    13. Tuan Nguyen & Sai Li & Jeremy T-H Chang & John W. Watters & Htet Ng & Adewola Osunsade & Yael David & Shixin Liu, 2022. "Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    14. Amanda Ames & Melissa Seman & Ajay Larkin & Gulzhan Raiymbek & Ziyuan Chen & Alex Levashkevich & Bokyung Kim & Julie Suzanne Biteen & Kaushik Ragunathan, 2024. "Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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