IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v545y2017i7653d10.1038_nature22306.html
   My bibliography  Save this article

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Author

Listed:
  • Claudia Y. Janda

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Luke T. Dang

    (Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington)

  • Changjiang You

    (University of Osnabrück)

  • Junlei Chang

    (Stanford University School of Medicine)

  • Wim de Lau

    (Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht)

  • Zhendong A. Zhong

    (Program for Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Research Institute)

  • Kelley S. Yan

    (Stanford University School of Medicine)

  • Owen Marecic

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Dirk Siepe

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Xingnan Li

    (Stanford University School of Medicine)

  • James D. Moody

    (Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington)

  • Bart O. Williams

    (Program for Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Research Institute)

  • Hans Clevers

    (Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht)

  • Jacob Piehler

    (University of Osnabrück)

  • David Baker

    (Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington)

  • Calvin J. Kuo

    (Stanford University School of Medicine)

  • K. Christopher Garcia

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

Abstract

The authors describe water-soluble surrogate Wnt agonists, with specificity towards some frizzled (FZD) receptors, which can maintain human intestinal organoid cultures and have effects on the mouse liver in vivo.

Suggested Citation

  • Claudia Y. Janda & Luke T. Dang & Changjiang You & Junlei Chang & Wim de Lau & Zhendong A. Zhong & Kelley S. Yan & Owen Marecic & Dirk Siepe & Xingnan Li & James D. Moody & Bart O. Williams & Hans Cle, 2017. "Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling," Nature, Nature, vol. 545(7653), pages 234-237, May.
  • Handle: RePEc:nat:nature:v:545:y:2017:i:7653:d:10.1038_nature22306
    DOI: 10.1038/nature22306
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature22306
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature22306?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. James Hillier & Yuguang Zhao & Loic Carrique & Tomas Malinauskas & Reinis R. Ruza & Tao-Hsin Chang & Gangshun Yi & Helen M. E. Duyvesteyn & Jing Yu & Weixian Lu & Els Pardon & Jan Steyaert & Yanan Zhu, 2024. "Structural insights into Frizzled3 through nanobody modulators," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Jie Ding & Sung-Jin Lee & Lukas Vlahos & Kanako Yuki & Cara C. Rada & Vincent Unen & Meghah Vuppalapaty & Hui Chen & Asmiti Sura & Aaron K. McCormick & Madeline Tomaske & Samira Alwahabi & Huy Nguyen , 2023. "Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Ohman Kwon & Hana Lee & Jaeeun Jung & Ye Seul Son & Sojeong Jeon & Won Dong Yoo & Naeun Son & Kwang Bo Jung & Eunho Choi & In-Chul Lee & Hyung-Jun Kwon & Chuna Kim & Mi-Ok Lee & Hyun-Soo Cho & Dae Soo, 2024. "Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:545:y:2017:i:7653:d:10.1038_nature22306. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.