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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Author

Listed:
  • Claudia Y. Janda

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Luke T. Dang

    (Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington)

  • Changjiang You

    (University of Osnabrück)

  • Junlei Chang

    (Stanford University School of Medicine)

  • Wim de Lau

    (Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht)

  • Zhendong A. Zhong

    (Program for Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Research Institute)

  • Kelley S. Yan

    (Stanford University School of Medicine)

  • Owen Marecic

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Dirk Siepe

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Xingnan Li

    (Stanford University School of Medicine)

  • James D. Moody

    (Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington)

  • Bart O. Williams

    (Program for Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Research Institute)

  • Hans Clevers

    (Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht)

  • Jacob Piehler

    (University of Osnabrück)

  • David Baker

    (Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington)

  • Calvin J. Kuo

    (Stanford University School of Medicine)

  • K. Christopher Garcia

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

Abstract

The authors describe water-soluble surrogate Wnt agonists, with specificity towards some frizzled (FZD) receptors, which can maintain human intestinal organoid cultures and have effects on the mouse liver in vivo.

Suggested Citation

  • Claudia Y. Janda & Luke T. Dang & Changjiang You & Junlei Chang & Wim de Lau & Zhendong A. Zhong & Kelley S. Yan & Owen Marecic & Dirk Siepe & Xingnan Li & James D. Moody & Bart O. Williams & Hans Cle, 2017. "Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling," Nature, Nature, vol. 545(7653), pages 234-237, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7653:d:10.1038_nature22306
    DOI: 10.1038/nature22306
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    Cited by:

    1. Ngee-Soon Lau & Geoffrey McCaughan & Mark Ly & Ken Liu & Michael Crawford & Carlo Pulitano, 2024. "Long-term machine perfusion of human split livers: a new model for regenerative and translational research," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. James Hillier & Yuguang Zhao & Loic Carrique & Tomas Malinauskas & Reinis R. Ruza & Tao-Hsin Chang & Gangshun Yi & Helen M. E. Duyvesteyn & Jing Yu & Weixian Lu & Els Pardon & Jan Steyaert & Yanan Zhu, 2024. "Structural insights into Frizzled3 through nanobody modulators," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Ohman Kwon & Hana Lee & Jaeeun Jung & Ye Seul Son & Sojeong Jeon & Won Dong Yoo & Naeun Son & Kwang Bo Jung & Eunho Choi & In-Chul Lee & Hyung-Jun Kwon & Chuna Kim & Mi-Ok Lee & Hyun-Soo Cho & Dae Soo, 2024. "Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Jie Ding & Sung-Jin Lee & Lukas Vlahos & Kanako Yuki & Cara C. Rada & Vincent Unen & Meghah Vuppalapaty & Hui Chen & Asmiti Sura & Aaron K. McCormick & Madeline Tomaske & Samira Alwahabi & Huy Nguyen , 2023. "Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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