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Designer matrices for intestinal stem cell and organoid culture

Author

Listed:
  • Nikolce Gjorevski

    (Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL))

  • Norman Sachs

    (Hubrecht Institute and University Medical Center Utrecht)

  • Andrea Manfrin

    (Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL))

  • Sonja Giger

    (Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL))

  • Maiia E. Bragina

    (Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL))

  • Paloma Ordóñez-Morán

    (Swiss Institute for Experimental Cancer Research (ISREC), EPFL)

  • Hans Clevers

    (Hubrecht Institute and University Medical Center Utrecht)

  • Matthias P. Lutolf

    (Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Institute of Chemical Sciences and Engineering, School of Basic Science, Ecole Polytechnique Fédérale de Lausanne (EPFL))

Abstract

The authors have designed modular synthetic hydrogel networks for mouse and human intestinal stem cell cultures that support intestinal organoid formation.

Suggested Citation

  • Nikolce Gjorevski & Norman Sachs & Andrea Manfrin & Sonja Giger & Maiia E. Bragina & Paloma Ordóñez-Morán & Hans Clevers & Matthias P. Lutolf, 2016. "Designer matrices for intestinal stem cell and organoid culture," Nature, Nature, vol. 539(7630), pages 560-564, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature20168
    DOI: 10.1038/nature20168
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    Cited by:

    1. Yongcheng Jin & Ellina Mikhailova & Ming Lei & Sally A. Cowley & Tianyi Sun & Xingyun Yang & Yujia Zhang & Kaili Liu & Daniel Catarino da Silva & Luana Campos Soares & Sara Bandiera & Francis G. Szele, 2023. "Integration of 3D-printed cerebral cortical tissue into an ex vivo lesioned brain slice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Bas Loo & Simone A. Den & Nuno Araújo-Gomes & Vincent Jong & Rebecca R. Snabel & Maik Schot & José M. Rivera-Arbeláez & Gert Jan C. Veenstra & Robert Passier & Tom Kamperman & Jeroen Leijten, 2023. "Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Mélanie T. M. Hannebelle & Esther Raeth & Samuel M. Leitao & Tomáš Lukeš & Jakub Pospíšil & Chiara Toniolo & Olivier F. Venzin & Antonius Chrisnandy & Prabhu P. Swain & Nathan Ronceray & Matthias P. L, 2024. "Open-source microscope add-on for structured illumination microscopy," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    4. Maisumu Gulimiheranmu & Shuang Li & Junmei Zhou, 2021. "In Vitro Recapitulation of Neuropsychiatric Disorders with Pluripotent Stem Cells-Derived Brain Organoids," IJERPH, MDPI, vol. 18(23), pages 1-14, November.
    5. Suran Kim & Sungjin Min & Yi Sun Choi & Sung-Hyun Jo & Jae Hun Jung & Kyusun Han & Jin Kim & Soohwan An & Yong Woo Ji & Yun-Gon Kim & Seung-Woo Cho, 2022. "Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    6. Abdel Rahman Abdel Fattah & Niko Kolaitis & Katrien Daele & Brian Daza & Andika Gregorius Rustandi & Adrian Ranga, 2023. "Targeted mechanical stimulation via magnetic nanoparticles guides in vitro tissue development," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Liang Yang & Zifeng Ruan & Xiaobing Lin & Hao Wang & Yanmin Xin & Haite Tang & Zhijuan Hu & Yunhao Zhou & Yi Wu & Junwei Wang & Dajiang Qin & Gang Lu & Kerry M. Loomes & Wai-Yee Chan & Xingguo Liu, 2024. "NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    8. Elisabeth Prince & Jennifer Cruickshank & Wail Ba-Alawi & Kelsey Hodgson & Jillian Haight & Chantal Tobin & Andrew Wakeman & Alona Avoulov & Valentina Topolskaia & Mitchell J. Elliott & Alison P. McGu, 2022. "Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Mara Martín-Alonso & Sharif Iqbal & Pia M. Vornewald & Håvard T. Lindholm & Mirjam J. Damen & Fernando Martínez & Sigrid Hoel & Alberto Díez-Sánchez & Maarten Altelaar & Pekka Katajisto & Alicia G. Ar, 2021. "Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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