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A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

Author

Listed:
  • Ai-Hui Tang

    (University of Maryland School of Medicine
    Program in Neuroscience, University of Maryland School of Medicine)

  • Haiwen Chen

    (University of Maryland School of Medicine
    Program in Neuroscience, University of Maryland School of Medicine
    Medical Scientist Training Program, University of Maryland School of Medicine)

  • Tuo P. Li

    (University of Maryland School of Medicine
    Program in Neuroscience, University of Maryland School of Medicine
    Medical Scientist Training Program, University of Maryland School of Medicine)

  • Sarah R. Metzbower

    (University of Maryland School of Medicine
    Program in Neuroscience, University of Maryland School of Medicine)

  • Harold D. MacGillavry

    (Cell Biology, Faculty of Science, Utrecht University)

  • Thomas A. Blanpied

    (University of Maryland School of Medicine
    Program in Neuroscience, University of Maryland School of Medicine)

Abstract

Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.

Suggested Citation

  • Ai-Hui Tang & Haiwen Chen & Tuo P. Li & Sarah R. Metzbower & Harold D. MacGillavry & Thomas A. Blanpied, 2016. "A trans-synaptic nanocolumn aligns neurotransmitter release to receptors," Nature, Nature, vol. 536(7615), pages 210-214, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7615:d:10.1038_nature19058
    DOI: 10.1038/nature19058
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    Cited by:

    1. Philipe R. F. Mendonça & Erica Tagliatti & Helen Langley & Dimitrios Kotzadimitriou & Criseida G. Zamora-Chimal & Yulia Timofeeva & Kirill E. Volynski, 2022. "Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Susanne Prokop & Péter Ábrányi-Balogh & Benjámin Barti & Márton Vámosi & Miklós Zöldi & László Barna & Gabriella M. Urbán & András Dávid Tóth & Barna Dudok & Attila Egyed & Hui Deng & Gian Marco Leggi, 2021. "PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    3. Alessandra Sclip & Thomas C. Südhof, 2023. "Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Aske L. Ejdrup & Matthew D. Lycas & Niels Lorenzen & Ainoa Konomi & Freja Herborg & Kenneth L. Madsen & Ulrik Gether, 2022. "A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Ling-Gang Wu & Chung Yu Chan, 2024. "Membrane transformations of fusion and budding," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    6. Nicky Scheefhals & Manon Westra & Harold D. MacGillavry, 2023. "mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Brian A Lloyd & Ying Han & Rebecca Roth & Bo Zhang & Jason Aoto, 2023. "Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    8. Wang, Xinyi & Zhang, Xiyun & Zheng, Muhua & Xu, Leijun & Xu, Kesheng, 2023. "Noise-induced coexisting firing patterns in hybrid-synaptic interacting networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 615(C).
    9. Céline D. Dürst & J. Simon Wiegert & Christian Schulze & Nordine Helassa & Katalin Török & Thomas G. Oertner, 2022. "Vesicular release probability sets the strength of individual Schaffer collateral synapses," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. Aseel Shomar & Lukas Geyrhofer & Noam E Ziv & Naama Brenner, 2017. "Cooperative stochastic binding and unbinding explain synaptic size dynamics and statistics," PLOS Computational Biology, Public Library of Science, vol. 13(7), pages 1-24, July.
    11. Konstantina Liouta & Malgorzata Lubas & Vasika Venugopal & Julia Chabbert & Caroline Jeannière & Candice Diaz & Matthieu Munier & Béatrice Tessier & Stéphane Claverol & Alexandre Favereaux & Matthieu , 2024. "LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    12. Xuchen Zhang & Pei-Yi Lin & Kif Liakath-Ali & Thomas C. Südhof, 2022. "Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    13. Martin Hruska & Rachel E. Cain & Matthew B. Dalva, 2022. "Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    14. Reagan L. Pennock & Luke T. Coddington & Xiaohui Yan & Linda Overstreet-Wadiche & Jacques I. Wadiche, 2023. "Afferent convergence to a shared population of interneuron AMPA receptors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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