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Afferent convergence to a shared population of interneuron AMPA receptors

Author

Listed:
  • Reagan L. Pennock

    (University of Alabama at Birmingham)

  • Luke T. Coddington

    (University of Alabama at Birmingham
    Howard Hughes Medical Institute Janelia Research Campus)

  • Xiaohui Yan

    (University of Alabama at Birmingham)

  • Linda Overstreet-Wadiche

    (University of Alabama at Birmingham)

  • Jacques I. Wadiche

    (University of Alabama at Birmingham)

Abstract

Precise alignment of pre- and postsynaptic elements optimizes the activation of glutamate receptors at excitatory synapses. Nonetheless, glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission called spillover. To uncover the extrasynaptic actions of glutamate, we localized AMPA receptors (AMPARs) mediating spillover transmission between climbing fibers and molecular layer interneurons in the cerebellar cortex. We found that climbing fiber spillover generates calcium transients mediated by Ca2+-permeable AMPARs at parallel fiber synapses. Spillover occludes parallel fiber synaptic currents, indicating that separate, independently regulated afferent pathways converge onto a common pool of AMPARs. Together these findings demonstrate a circuit motif wherein glutamate ‘spill-in’ from an unconnected afferent pathway co-opts synaptic receptors, allowing activation of postsynaptic AMPARs even when canonical glutamate release is suppressed.

Suggested Citation

  • Reagan L. Pennock & Luke T. Coddington & Xiaohui Yan & Linda Overstreet-Wadiche & Jacques I. Wadiche, 2023. "Afferent convergence to a shared population of interneuron AMPA receptors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38854-2
    DOI: 10.1038/s41467-023-38854-2
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    References listed on IDEAS

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    1. Si-Qiong June Liu & Stuart G. Cull-Candy, 2000. "Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype," Nature, Nature, vol. 405(6785), pages 454-458, May.
    2. Ai-Hui Tang & Haiwen Chen & Tuo P. Li & Sarah R. Metzbower & Harold D. MacGillavry & Thomas A. Blanpied, 2016. "A trans-synaptic nanocolumn aligns neurotransmitter release to receptors," Nature, Nature, vol. 536(7615), pages 210-214, August.
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