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Ki-67 acts as a biological surfactant to disperse mitotic chromosomes

Author

Listed:
  • Sara Cuylen

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC))

  • Claudia Blaukopf

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC))

  • Antonio Z. Politi

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL))

  • Thomas Müller-Reichert

    (Medical Faculty Carl Gustav Carus, Experimental Center, Technische Universität Dresden)

  • Beate Neumann

    (Advanced Light Microscopy Facility, European Molecular Biology Laboratory (EMBL))

  • Ina Poser

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Jan Ellenberg

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL))

  • Anthony A. Hyman

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Daniel W. Gerlich

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC))

Abstract

During cell division, chromosomes are maintained as individual units; this process is shown to be mediated by the cell proliferation marker Ki-67, which has biophysical properties similar to those of surfactants.

Suggested Citation

  • Sara Cuylen & Claudia Blaukopf & Antonio Z. Politi & Thomas Müller-Reichert & Beate Neumann & Ina Poser & Jan Ellenberg & Anthony A. Hyman & Daniel W. Gerlich, 2016. "Ki-67 acts as a biological surfactant to disperse mitotic chromosomes," Nature, Nature, vol. 535(7611), pages 308-312, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7611:d:10.1038_nature18610
    DOI: 10.1038/nature18610
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    Cited by:

    1. Kayo Hibino & Yuji Sakai & Sachiko Tamura & Masatoshi Takagi & Katsuhiko Minami & Toyoaki Natsume & Masa A. Shimazoe & Masato T. Kanemaki & Naoko Imamoto & Kazuhiro Maeshima, 2024. "Single-nucleosome imaging unveils that condensins and nucleosome–nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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