IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-56090-8.html
   My bibliography  Save this article

Mitotic chromatin marking governs the segregation of DNA damage

Author

Listed:
  • Juliette Ferrand

    (UMR7216 CNRS, Université Paris Cité)

  • Juliette Dabin

    (UMR7216 CNRS, Université Paris Cité)

  • Odile Chevallier

    (UMR7216 CNRS, Université Paris Cité)

  • Matteo Kane-Charvin

    (UMR7216 CNRS, Université Paris Cité)

  • Ariana Kupai

    (Van Andel Institute)

  • Joel Hrit

    (Van Andel Institute)

  • Scott B. Rothbart

    (Van Andel Institute)

  • Sophie E. Polo

    (UMR7216 CNRS, Université Paris Cité)

Abstract

The faithful segregation of intact genetic material and the perpetuation of chromatin states through mitotic cell divisions are pivotal for maintaining cell function and identity across cell generations. However, most exogenous mutagens generate long-lasting DNA lesions that are segregated during mitosis. How this segregation is controlled is unknown. Here, we uncover a mitotic chromatin-marking pathway that governs the segregation of UV-induced damage in human cells. Our mechanistic analyses reveal two layers of control: histone ADP-ribosylation, and the incorporation of newly synthesized histones at UV damage sites, that both prevent local mitotic phosphorylations on histone H3 serine residues. Functionally, this chromatin-marking pathway controls the segregation of UV damage in the cell progeny with consequences on daughter cell fate. We propose that this mechanism may help preserve the integrity of stem cell compartments during asymmetric cell divisions.

Suggested Citation

  • Juliette Ferrand & Juliette Dabin & Odile Chevallier & Matteo Kane-Charvin & Ariana Kupai & Joel Hrit & Scott B. Rothbart & Sophie E. Polo, 2025. "Mitotic chromatin marking governs the segregation of DNA damage," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56090-8
    DOI: 10.1038/s41467-025-56090-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-56090-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-56090-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56090-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.