A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice
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DOI: 10.1038/s41467-022-34801-9
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- Darren J. Baker & Tobias Wijshake & Tamar Tchkonia & Nathan K. LeBrasseur & Bennett G. Childs & Bart van de Sluis & James L. Kirkland & Jan M. van Deursen, 2011. "Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders," Nature, Nature, vol. 479(7372), pages 232-236, November.
- Darren J. Baker & Bennett G. Childs & Matej Durik & Melinde E. Wijers & Cynthia J. Sieben & Jian Zhong & Rachel A. Saltness & Karthik B. Jeganathan & Grace Casaclang Verzosa & Abdulmohammad Pezeshki &, 2016. "Naturally occurring p16Ink4a-positive cells shorten healthy lifespan," Nature, Nature, vol. 530(7589), pages 184-189, February.
- Eladio J. Márquez & Cheng-han Chung & Radu Marches & Robert J. Rossi & Djamel Nehar-Belaid & Alper Eroglu & David J. Mellert & George A. Kuchel & Jacques Banchereau & Duygu Ucar, 2020. "Sexual-dimorphism in human immune system aging," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
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