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MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

Author

Listed:
  • Vera Boersma

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

  • Nathalie Moatti

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

  • Sandra Segura-Bayona

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

  • Marieke H. Peuscher

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

  • Jaco van der Torre

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

  • Brigitte A. Wevers

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

  • Alexandre Orthwein

    (The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Daniel Durocher

    (The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    University of Toronto, Ontario M5S 3E1, Canada)

  • Jacqueline J. L. Jacobs

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands)

Abstract

MAD2L2 regulates DNA repair at deprotected telomeres and at ionizing-radiation-induced double-stranded DNA breaks by inhibiting resection of the 5′ ends; the ends are thus shunted into the non-homologous end-joining pathway.

Suggested Citation

  • Vera Boersma & Nathalie Moatti & Sandra Segura-Bayona & Marieke H. Peuscher & Jaco van der Torre & Brigitte A. Wevers & Alexandre Orthwein & Daniel Durocher & Jacqueline J. L. Jacobs, 2015. "MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection," Nature, Nature, vol. 521(7553), pages 537-540, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7553:d:10.1038_nature14216
    DOI: 10.1038/nature14216
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    Citations

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    Cited by:

    1. Yajie Sun & Jeffrey Patterson-Fortin & Sen Han & Zhe Li & Zuzanna Nowicka & Yuna Hirohashi & Susan Kilgas & Jae Kyo Yi & Alexander Spektor & Wojciech Fendler & Panagiotis A. Konstantinopoulos & Dipanj, 2024. "53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Zeliha Yalçin & Shiu Yeung Lam & Marieke H. Peuscher & Jaco Torre & Sha Zhu & Prasanna V. Iyengar & Daniel Salas-Lloret & Inge Krijger & Nathalie Moatti & Ruben Lugt & Mattia Falcone & Aurora Cerutti , 2024. "UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Inés Paniagua & Zainab Tayeh & Mattia Falcone & Santiago Hernández Pérez & Aurora Cerutti & Jacqueline J. L. Jacobs, 2022. "MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Shiu Yeung Lam & Ruben Lugt & Aurora Cerutti & Zeliha Yalçin & Alexander M. Thouin & Marco Simonetta & Jacqueline J. L. Jacobs, 2024. "OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Estelle Vincendeau & Wenming Wei & Xuefei Zhang & Cyril Planchais & Wei Yu & Hélène Lenden-Hasse & Thomas Cokelaer & Juliana Pipoli da Fonseca & Hugo Mouquet & David J. Adams & Frederick W. Alt & Step, 2022. "SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Sumin Feng & Sai Ma & Kejiao Li & Shengxian Gao & Shaokai Ning & Jinfeng Shang & Ruiyuan Guo & Yingying Chen & Britny Blumenfeld & Itamar Simon & Qing Li & Rong Guo & Dongyi Xu, 2022. "RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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