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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Author

Listed:
  • Yukihiro Furusawa

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan)

  • Yuuki Obata

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
    Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan)

  • Shinji Fukuda

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan)

  • Takaho A. Endo

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Gaku Nakato

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Daisuke Takahashi

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Yumiko Nakanishi

    (Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan)

  • Chikako Uetake

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Keiko Kato

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan)

  • Tamotsu Kato

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Masumi Takahashi

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Noriko N. Fukuda

    (Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan)

  • Shinnosuke Murakami

    (Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan)

  • Eiji Miyauchi

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Shingo Hino

    (Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan)

  • Koji Atarashi

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Satoshi Onawa

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Yumiko Fujimura

    (The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan)

  • Trevor Lockett

    (Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia)

  • Julie M. Clarke

    (Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia)

  • David L. Topping

    (Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia)

  • Masaru Tomita

    (Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan)

  • Shohei Hori

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Osamu Ohara

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan)

  • Tatsuya Morita

    (Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan)

  • Haruhiko Koseki

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan)

  • Jun Kikuchi

    (Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan
    RIKEN Center for Sustainable Resource Science, Kanagawa 230-0045, Japan)

  • Kenya Honda

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Koji Hase

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
    PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Hiroshi Ohno

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
    Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan)

Abstract

The gut microbial metabolite butyrate is shown to induce the differentiation of colonic T regulatory cells in mice and to ameliorate the development of colitis; it also increases histone H3 acetylation at the Foxp3 promoter.

Suggested Citation

  • Yukihiro Furusawa & Yuuki Obata & Shinji Fukuda & Takaho A. Endo & Gaku Nakato & Daisuke Takahashi & Yumiko Nakanishi & Chikako Uetake & Keiko Kato & Tamotsu Kato & Masumi Takahashi & Noriko N. Fukuda, 2013. "Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells," Nature, Nature, vol. 504(7480), pages 446-450, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12721
    DOI: 10.1038/nature12721
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    Cited by:

    1. Yanan Zhang & Shuyu Tu & Xingwei Ji & Jianan Wu & Jinxin Meng & Jinsong Gao & Xian Shao & Shuai Shi & Gan Wang & Jingjing Qiu & Zhuobiao Zhang & Chengang Hua & Ziyi Zhang & Shuxian Chen & Li Zhang & S, 2024. "Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Koji Hosomi & Mayu Saito & Jonguk Park & Haruka Murakami & Naoko Shibata & Masahiro Ando & Takahiro Nagatake & Kana Konishi & Harumi Ohno & Kumpei Tanisawa & Attayeb Mohsen & Yi-An Chen & Hitoshi Kawa, 2022. "Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Felipe Papa Pellizoni & Aline Zazeri Leite & Nathália de Campos Rodrigues & Marcelo Jordão Ubaiz & Marina Ignácio Gonzaga & Nauyta Naomi Campos Takaoka & Vânia Sammartino Mariano & Wellington Pine Omo, 2021. "Detection of Dysbiosis and Increased Intestinal Permeability in Brazilian Patients with Relapsing–Remitting Multiple Sclerosis," IJERPH, MDPI, vol. 18(9), pages 1-17, April.
    4. Natsuko Tabata & Mai Tsukada & Kozue Kubo & Yuri Inoue & Reiko Miroku & Fumihiko Odashima & Koichiro Shiratori & Takashi Sekiya & Shintaro Sengoku & Hideaki Shiroyama & Hiromichi Kimura, 2022. "Living Lab for Citizens’ Wellness: A Case of Maintaining and Improving a Healthy Diet under the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(3), pages 1-17, January.
    5. Alba Ordoñez-Rodriguez & Pablo Roman & Lola Rueda-Ruzafa & Ana Campos-Rios & Diana Cardona, 2023. "Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review," IJERPH, MDPI, vol. 20(5), pages 1-16, March.
    6. Todd D. Terhune & Richard C. Deth, 2018. "Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible Subpopulation?," IJERPH, MDPI, vol. 15(5), pages 1-16, May.
    7. Natalia Di Tommaso & Antonio Gasbarrini & Francesca Romana Ponziani, 2021. "Intestinal Barrier in Human Health and Disease," IJERPH, MDPI, vol. 18(23), pages 1-23, December.
    8. Lei Zhu & Xingxing Jian & Bingjing Zhou & Runqiu Liu & Melba Muñoz & Wan Sun & Lu Xie & Xiang Chen & Cong Peng & Marcus Maurer & Jie Li, 2024. "Gut microbiota facilitate chronic spontaneous urticaria," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    9. Junling Niu & Mengmeng Cui & Xin Yang & Juan Li & Yuhui Yao & Qiuhong Guo & Ailing Lu & Xiaopeng Qi & Dongming Zhou & Chenhong Zhang & Liping Zhao & Guangxun Meng, 2023. "Microbiota-derived acetate enhances host antiviral response via NLRP3," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    10. Minami Nagai & Miyu Moriyama & Chiharu Ishii & Hirotake Mori & Hikaru Watanabe & Taku Nakahara & Takuji Yamada & Dai Ishikawa & Takamasa Ishikawa & Akiyoshi Hirayama & Ikuo Kimura & Akihito Nagahara &, 2023. "High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    11. Kamila Gorczyca & Aleksandra Obuchowska & Żaneta Kimber-Trojnar & Magdalena Wierzchowska-Opoka & Bożena Leszczyńska-Gorzelak, 2022. "Changes in the Gut Microbiome and Pathologies in Pregnancy," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    12. Hung-Chih Chen & Yen-Wen Liu & Kuan-Cheng Chang & Yen-Wen Wu & Yi-Ming Chen & Yu-Kai Chao & Min-Yi You & David J. Lundy & Chen-Ju Lin & Marvin L. Hsieh & Yu-Che Cheng & Ray P. Prajnamitra & Po-Ju Lin , 2023. "Gut butyrate-producers confer post-infarction cardiac protection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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