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Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice

Author

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  • Suzanne Devkota

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Yunwei Wang

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Mark W. Musch

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Vanessa Leone

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Hannah Fehlner-Peach

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Anuradha Nadimpalli

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Dionysios A. Antonopoulos

    (Institute for Genomics and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA)

  • Bana Jabri

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

  • Eugene B. Chang

    (Section of Gastroenterology, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, Illinois 60637, USA)

Abstract

Consumption of a diet high in milk-derived fat is shown to increase the abundance of sulphite-reducing bacteria by altering bile composition, leading to inflammation and colitis in genetically susceptible mice.

Suggested Citation

  • Suzanne Devkota & Yunwei Wang & Mark W. Musch & Vanessa Leone & Hannah Fehlner-Peach & Anuradha Nadimpalli & Dionysios A. Antonopoulos & Bana Jabri & Eugene B. Chang, 2012. "Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice," Nature, Nature, vol. 487(7405), pages 104-108, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7405:d:10.1038_nature11225
    DOI: 10.1038/nature11225
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    Cited by:

    1. Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. M. C. Ramaboli & S. Ocvirk & M. Khan Mirzaei & B. L. Eberhart & M. Valdivia-Garcia & A. Metwaly & K. Neuhaus & G. Barker & J. Ru & L. T. Nesengani & D. Mahdi-Joest & A. S. Wilson & S. K. Joni & D. C. , 2024. "Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Jianan Zhang & Morgan E. Walker & Katherine Z. Sanidad & Hongna Zhang & Yanshan Liang & Ermin Zhao & Katherine Chacon-Vargas & Vladimir Yeliseyev & Julie Parsonnet & Thomas D. Haggerty & Guangqiang Wa, 2022. "Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Kang Li & Zeng Dan & Luobu Gesang & Hong Wang & Yongjian Zhou & Yanlei Du & Yi Ren & Yixiang Shi & Yuqiang Nie, 2016. "Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-16, May.
    5. Wenjie Ma & Yiqing Wang & Long H. Nguyen & Raaj S. Mehta & Jane Ha & Amrisha Bhosle & Lauren J. Mclver & Mingyang Song & Clary B. Clish & Lisa L. Strate & Curtis Huttenhower & Andrew T. Chan, 2024. "Gut microbiome composition and metabolic activity in women with diverticulitis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Marc Schoeler & Sandrine Ellero-Simatos & Till Birkner & Jordi Mayneris-Perxachs & Lisa Olsson & Harald Brolin & Ulrike Loeber & Jamie D. Kraft & Arnaud Polizzi & Marian Martí-Navas & Josep Puig & Ant, 2023. "The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Kotaro Soeda & Takayoshi Sasako & Kenichiro Enooku & Naoto Kubota & Naoki Kobayashi & Yoshiko Matsumoto Ikushima & Motoharu Awazawa & Ryotaro Bouchi & Gotaro Toda & Tomoharu Yamada & Takuma Nakatsuka , 2023. "Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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