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Engineering the third wave of biocatalysis

Author

Listed:
  • U. T. Bornscheuer

    (Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Straße 4, D-17487 Greifswald, Germany)

  • G. W. Huisman

    (Codexis Inc., 200 Penobscot Drive)

  • R. J. Kazlauskas

    (Molecular Biology and Biophysics, Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, Minnesota 55108, USA
    Seoul National University, Seoul 151-744, Korea)

  • S. Lutz

    (Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA)

  • J. C. Moore

    (Merck Research Laboratories, Merck & Co.)

  • K. Robins

    (Lonza AG, Valais Works, CH-3930 Visp, Switzerland)

Abstract

Over the past ten years, scientific and technological advances have established biocatalysis as a practical and environmentally friendly alternative to traditional metallo- and organocatalysis in chemical synthesis, both in the laboratory and on an industrial scale. Key advances in DNA sequencing and gene synthesis are at the base of tremendous progress in tailoring biocatalysts by protein engineering and design, and the ability to reorganize enzymes into new biosynthetic pathways. To highlight these achievements, here we discuss applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step.

Suggested Citation

  • U. T. Bornscheuer & G. W. Huisman & R. J. Kazlauskas & S. Lutz & J. C. Moore & K. Robins, 2012. "Engineering the third wave of biocatalysis," Nature, Nature, vol. 485(7397), pages 185-194, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature11117
    DOI: 10.1038/nature11117
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    Citations

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    Cited by:

    1. Cottier, Thomas & Foltea, Marina & Jost, Dannie, 2012. "Is there a case to be made for a global patent system? The example of plant biotechnology," Papers 428, World Trade Institute.
    2. Ziyi Zhou & Liang Zhang & Yuanxi Yu & Banghao Wu & Mingchen Li & Liang Hong & Pan Tan, 2024. "Enhancing efficiency of protein language models with minimal wet-lab data through few-shot learning," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Qiuge Zhang & Samira M. Azarin & Casim A. Sarkar, 2022. "Model-guided engineering of DNA sequences with predictable site-specific recombination rates," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Kerr Ding & Michael Chin & Yunlong Zhao & Wei Huang & Binh Khanh Mai & Huanan Wang & Peng Liu & Yang Yang & Yunan Luo, 2024. "Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineering," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Chenghai Sun & Gen Lu & Baoming Chen & Guangjun Li & Ya Wu & Yannik Brack & Dong Yi & Yu-Fei Ao & Shuke Wu & Ren Wei & Yuhui Sun & Guifa Zhai & Uwe T. Bornscheuer, 2024. "Direct asymmetric synthesis of β-branched aromatic α-amino acids using engineered phenylalanine ammonia lyases," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Aiko Kurimoto & Seyed A. Nasseri & Camden Hunt & Mike Rooney & David J. Dvorak & Natalie E. LeSage & Ryan P. Jansonius & Stephen G. Withers & Curtis P. Berlinguette, 2023. "Bioelectrocatalysis with a palladium membrane reactor," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    7. Wei Huang & Haitao Yuan & Huangsheng Yang & Xiaomin Ma & Shuyao Huang & Hongjie Zhang & Siming Huang & Guosheng Chen & Gangfeng Ouyang, 2023. "Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    8. Zhe Dou & Xuanzao Chen & Ledong Zhu & Xiangyu Zheng & Xiaoyu Chen & Jiayu Xue & Satomi Niwayama & Ye Ni & Guochao Xu, 2024. "Enhanced stereodivergent evolution of carboxylesterase for efficient kinetic resolution of near-symmetric esters through machine learning," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Peihui Li & Songjun Hou & Qingqing Wu & Yijian Chen & Boyu Wang & Haiyang Ren & Jinying Wang & Zhaoyi Zhai & Zhongbo Yu & Colin J. Lambert & Chuancheng Jia & Xuefeng Guo, 2023. "The role of halogens in Au–S bond cleavage for energy-differentiated catalysis at the single-bond limit," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    10. Ke Li & Yucheng Zhao & Jian Yang & Jinlou Gu, 2022. "Nanoemulsion-directed growth of MOFs with versatile architectures for the heterogeneous regeneration of coenzymes," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    11. Shuyun Ju & Kaylee P. Kuzelka & Rui Guo & Benjamin Krohn-Hansen & Jianping Wu & Satish K. Nair & Yang Yang, 2023. "A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    12. Le Quang Anh Tuan, 2018. "Rational protein design for enhancing thermal stability of industrial enzymes," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 3-17.

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