IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v485y2012i7397d10.1038_nature11117.html
   My bibliography  Save this article

Engineering the third wave of biocatalysis

Author

Listed:
  • U. T. Bornscheuer

    (Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Straße 4, D-17487 Greifswald, Germany)

  • G. W. Huisman

    (Codexis Inc., 200 Penobscot Drive)

  • R. J. Kazlauskas

    (Molecular Biology and Biophysics, Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, Minnesota 55108, USA
    Seoul National University, Seoul 151-744, Korea)

  • S. Lutz

    (Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA)

  • J. C. Moore

    (Merck Research Laboratories, Merck & Co.)

  • K. Robins

    (Lonza AG, Valais Works, CH-3930 Visp, Switzerland)

Abstract

Over the past ten years, scientific and technological advances have established biocatalysis as a practical and environmentally friendly alternative to traditional metallo- and organocatalysis in chemical synthesis, both in the laboratory and on an industrial scale. Key advances in DNA sequencing and gene synthesis are at the base of tremendous progress in tailoring biocatalysts by protein engineering and design, and the ability to reorganize enzymes into new biosynthetic pathways. To highlight these achievements, here we discuss applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step.

Suggested Citation

  • U. T. Bornscheuer & G. W. Huisman & R. J. Kazlauskas & S. Lutz & J. C. Moore & K. Robins, 2012. "Engineering the third wave of biocatalysis," Nature, Nature, vol. 485(7397), pages 185-194, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature11117
    DOI: 10.1038/nature11117
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11117
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11117?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Cottier, Thomas & Foltea, Marina & Jost, Dannie, 2012. "Is there a case to be made for a global patent system? The example of plant biotechnology," Papers 428, World Trade Institute.
    2. Qiuge Zhang & Samira M. Azarin & Casim A. Sarkar, 2022. "Model-guided engineering of DNA sequences with predictable site-specific recombination rates," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Aiko Kurimoto & Seyed A. Nasseri & Camden Hunt & Mike Rooney & David J. Dvorak & Natalie E. LeSage & Ryan P. Jansonius & Stephen G. Withers & Curtis P. Berlinguette, 2023. "Bioelectrocatalysis with a palladium membrane reactor," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Wei Huang & Haitao Yuan & Huangsheng Yang & Xiaomin Ma & Shuyao Huang & Hongjie Zhang & Siming Huang & Guosheng Chen & Gangfeng Ouyang, 2023. "Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    5. Peihui Li & Songjun Hou & Qingqing Wu & Yijian Chen & Boyu Wang & Haiyang Ren & Jinying Wang & Zhaoyi Zhai & Zhongbo Yu & Colin J. Lambert & Chuancheng Jia & Xuefeng Guo, 2023. "The role of halogens in Au–S bond cleavage for energy-differentiated catalysis at the single-bond limit," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    6. Ke Li & Yucheng Zhao & Jian Yang & Jinlou Gu, 2022. "Nanoemulsion-directed growth of MOFs with versatile architectures for the heterogeneous regeneration of coenzymes," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    7. Shuyun Ju & Kaylee P. Kuzelka & Rui Guo & Benjamin Krohn-Hansen & Jianping Wu & Satish K. Nair & Yang Yang, 2023. "A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    8. Le Quang Anh Tuan, 2018. "Rational protein design for enhancing thermal stability of industrial enzymes," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 3-17.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature11117. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.