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Optogenetic stimulation of a hippocampal engram activates fear memory recall

Author

Listed:
  • Xu Liu

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Steve Ramirez

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Petti T. Pang

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Corey B. Puryear

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Arvind Govindarajan

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Karl Deisseroth

    (Stanford University)

  • Susumu Tonegawa

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

Abstract

The activation of a population of hippocampal neurons thought to encode a specific fear memory is shown to elicit freezing behaviour in mice.

Suggested Citation

  • Xu Liu & Steve Ramirez & Petti T. Pang & Corey B. Puryear & Arvind Govindarajan & Karl Deisseroth & Susumu Tonegawa, 2012. "Optogenetic stimulation of a hippocampal engram activates fear memory recall," Nature, Nature, vol. 484(7394), pages 381-385, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7394:d:10.1038_nature11028
    DOI: 10.1038/nature11028
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    1. Francesco Paolo Ulloa Severino & Oluwadamilola O. Lawal & Kristina Sakers & Shiyi Wang & Namsoo Kim & Alexander David Friedman & Sarah Anne Johnson & Chaichontat Sriworarat & Ryan H. Hughes & Scott H., 2023. "Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Meng Wang & Ke Liu & Junxia Pan & Jialin Li & Pei Sun & Yongsheng Zhang & Longhui Li & Wenyan Guo & Qianqian Xin & Zhikai Zhao & Yurong Liu & Zhenqiao Zhou & Jing Lyu & Ting Zheng & Yunyun Han & Chunq, 2022. "Brain-wide projection reconstruction of single functionally defined neurons," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Tamás Füzesi & Neilen P. Rasiah & David G. Rosenegger & Mijail Rojas-Carvajal & Taylor Chomiak & Núria Daviu & Leonardo A. Molina & Kathryn Simone & Toni-Lee Sterley & Wilten Nicola & Jaideep S. Bains, 2023. "Hypothalamic CRH neurons represent physiological memory of positive and negative experience," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Sorinel A Oprisan & Xandre Clementsmith & Tamas Tompa & Antonieta Lavin, 2019. "Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-39, October.
    5. Wenhan Luo & Di Yun & Yi Hu & Miaomiao Tian & Jiajun Yang & Yifan Xu & Yong Tang & Yang Zhan & Hong Xie & Ji-Song Guan, 2022. "Acquiring new memories in neocortex of hippocampal-lesioned mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Ayush Mandwal & Javier G Orlandi & Christoph Simon & Jörn Davidsen, 2021. "A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-34, May.
    7. Dheeraj S. Roy & Young-Gyun Park & Minyoung E. Kim & Ying Zhang & Sachie K. Ogawa & Nicholas DiNapoli & Xinyi Gu & Jae H. Cho & Heejin Choi & Lee Kamentsky & Jared Martin & Olivia Mosto & Tomomi Aida , 2022. "Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Ruijie Li & Junjie Huang & Longhui Li & Zhikai Zhao & Susu Liang & Shanshan Liang & Meng Wang & Xiang Liao & Jing Lyu & Zhenqiao Zhou & Sibo Wang & Wenjun Jin & Haiyang Chen & Damaris Holder & Hongban, 2023. "Holistic bursting cells store long-term memory in auditory cortex," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    9. Heather C. Ratigan & Seetha Krishnan & Shai Smith & Mark E. J. Sheffield, 2023. "A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    10. Yann Vanrobaeys & Utsav Mukherjee & Lucy Langmack & Stacy E. Beyer & Ethan Bahl & Li-Chun Lin & Jacob J. Michaelson & Ted Abel & Snehajyoti Chatterjee, 2023. "Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    11. Montangie, Lisandro & Montani, Fernando, 2015. "Quantifying higher-order correlations in a neuronal pool," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 421(C), pages 388-400.
    12. Paul J. Lamothe-Molina & Andreas Franzelin & Lennart Beck & Dong Li & Lea Auksutat & Tim Fieblinger & Laura Laprell & Joachim Alhbeck & Christine E. Gee & Matthias Kneussel & Andreas K. Engel & Claus , 2022. "ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    13. Chih-Ming Wang & Chun-Yuan Wu & Chen-En Lin & Ming-Chi Hsu & Jing-Chun Lin & Chuan-Chin Huang & Ting-Yu Lien & Hsin-Kai Lin & Ting-Wei Chang & Hsueh-Cheng Chiang, 2023. "Forgotten memory storage and retrieval in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    14. Joseph I. Terranova & Jun Yokose & Hisayuki Osanai & Sachie K. Ogawa & Takashi Kitamura, 2023. "Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    15. Jun Liu & Arron F. Hall & Dong V. Wang, 2024. "Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    16. Xiaocen Fan & Jiachen Song & Chaonan Ma & Yanbo Lv & Feifei Wang & Lan Ma & Xing Liu, 2022. "Noradrenergic signaling mediates cortical early tagging and storage of remote memory," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    17. Stephanie L. Grella & Amanda H. Fortin & Evan Ruesch & John H. Bladon & Leanna F. Reynolds & Abby Gross & Monika Shpokayte & Christine Cincotta & Yosif Zaki & Steve Ramirez, 2022. "Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    18. Jung Ho Hyun & Kenichiro Nagahama & Ho Namkung & Neymi Mignocchi & Seung-Eon Roh & Patrick Hannan & Sarah Krüssel & Chuljung Kwak & Abigail McElroy & Bian Liu & Mingguang Cui & Seunghwan Lee & Dongmin, 2022. "Tagging active neurons by soma-targeted Cal-Light," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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