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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

Author

Listed:
  • Jeremy Schwartzentruber

    (McGill University and Genome Quebec Innovation Centre)

  • Andrey Korshunov

    (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Xiao-Yang Liu

    (McGill University, Montreal, H3Z 2Z3, Canada)

  • David T. W. Jones

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Elke Pfaff

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Karine Jacob

    (McGill University, Montreal, H3Z 2Z3, Canada)

  • Dominik Sturm

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Adam M. Fontebasso

    (McGill University, Montreal, H3Z 2Z3, Canada)

  • Dong-Anh Khuong Quang

    (McGill University, Montreal, H3Z 2Z3, Canada)

  • Martje Tönjes

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Volker Hovestadt

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Steffen Albrecht

    (Montreal Children’s Hospital, McGill University Health Center, Montreal, Quebec H3H 1P3, Canada)

  • Marcel Kool

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Andre Nantel

    (Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada)

  • Carolin Konermann

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Anders Lindroth

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Natalie Jäger

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Tobias Rausch

    (European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany)

  • Marina Ryzhova

    (Burdenko Neurosurgical Institute, 125047 Moscow, Russia)

  • Jan O. Korbel

    (European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany)

  • Thomas Hielscher

    (German Cancer Research Center (DKFZ))

  • Peter Hauser

    (Semmelweis University)

  • Miklos Garami

    (Semmelweis University)

  • Almos Klekner

    (Medical and Health Science Center, University of Debrecen)

  • Laszlo Bognar

    (Medical and Health Science Center, University of Debrecen)

  • Martin Ebinger

    (Children’s University Hospital, 72076 Tübingen, Germany)

  • Martin U. Schuhmann

    (University Hospital, 72076 Tübingen, Germany)

  • Wolfram Scheurlen

    (Cnopfsche Kinderklinik, Nuremberg Children’s Hospital, 90419 Nuremberg, Germany)

  • Arnulf Pekrun

    (Prof. Hess Children’s Hospital, 28177 Bremen, Germany)

  • Michael C. Frühwald

    (Klinikum Augsburg, Augsburg Children’s Hospital, 86156 Augsburg, Germany)

  • Wolfgang Roggendorf

    (Institute of Pathology, University of Würzburg, 97080 Würzburg, Germany)

  • Christoph Kramm

    (University Children’s Hospital, 06097 Halle, Germany)

  • Matthias Dürken

    (University Children’s Hospital, 68167 Mannheim, Germany)

  • Jeffrey Atkinson

    (Montreal Children’s Hospital, McGill University Health Centre, Montreal, Quebec H3H 1P3, Canada)

  • Pierre Lepage

    (McGill University and Genome Quebec Innovation Centre)

  • Alexandre Montpetit

    (McGill University and Genome Quebec Innovation Centre)

  • Magdalena Zakrzewska

    (Medical University of Lodz, 92-216 Poland)

  • Krzystof Zakrzewski

    (Polish Mother’s Memorial Hospital Research Institute, Lodz, 93-338 Poland)

  • Pawel P. Liberski

    (Medical University of Lodz, 92-216 Poland)

  • Zhifeng Dong

    (Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada)

  • Peter Siegel

    (Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada)

  • Andreas E. Kulozik

    (Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany)

  • Marc Zapatka

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Abhijit Guha

    (The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada)

  • David Malkin

    (The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada)

  • Jörg Felsberg

    (Heinrich-Heine-University, 40225 Düsseldorf, Germany)

  • Guido Reifenberger

    (Heinrich-Heine-University, 40225 Düsseldorf, Germany)

  • Andreas von Deimling

    (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Heidelberg University Hospital, 69120 Heidelberg Germany)

  • Koichi Ichimura

    (University of Cambridge)

  • V. Peter Collins

    (University of Cambridge)

  • Hendrik Witt

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany)

  • Till Milde

    (Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Clinical Cooperation Unit Paediatric Oncology, German Cancer Research Center, 69120 Heidelberg, Germany)

  • Olaf Witt

    (Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Clinical Cooperation Unit Paediatric Oncology, German Cancer Research Center, 69120 Heidelberg, Germany)

  • Cindy Zhang

    (The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada)

  • Pedro Castelo-Branco

    (The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada)

  • Peter Lichter

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Damien Faury

    (McGill University, Montreal, H3Z 2Z3, Canada)

  • Uri Tabori

    (The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario M5G1X8, Canada
    The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada)

  • Christoph Plass

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Jacek Majewski

    (McGill University, Montreal, H3Z 2Z3, Canada)

  • Stefan M. Pfister

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany)

  • Nada Jabado

    (McGill University, Montreal, H3Z 2Z3, Canada
    McGill University and the McGill University Health Center Research Institute, Montreal, Quebec H3Z 2Z3, Canada)

Abstract

Recurrent histone mutations are linked to paediatric glioblastoma multiforme, an aggressive type of brain tumour.

Suggested Citation

  • Jeremy Schwartzentruber & Andrey Korshunov & Xiao-Yang Liu & David T. W. Jones & Elke Pfaff & Karine Jacob & Dominik Sturm & Adam M. Fontebasso & Dong-Anh Khuong Quang & Martje Tönjes & Volker Hovesta, 2012. "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma," Nature, Nature, vol. 482(7384), pages 226-231, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10833
    DOI: 10.1038/nature10833
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    Citations

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    Cited by:

    1. Faye M. Walker & Lays Martin Sobral & Etienne Danis & Bridget Sanford & Sahiti Donthula & Ilango Balakrishnan & Dong Wang & Angela Pierce & Sana D. Karam & Soudabeh Kargar & Natalie J. Serkova & Nicho, 2024. "Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Benjamin A. Nacev & Yakshi Dabas & Matthew R. Paul & Christian Pacheco & Michelle Mitchener & Yekaterina Perez & Yan Fang & Alexey A. Soshnev & Douglas Barrows & Thomas Carroll & Nicholas D. Socci & S, 2024. "Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Augusto Faria Andrade & Alva Annett & Elham Karimi & Danai Georgia Topouza & Morteza Rezanejad & Yitong Liu & Michael McNicholas & Eduardo G. Gonzalez Santiago & Dhana Llivichuzhca-Loja & Arne Gehlhaa, 2024. "Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Fei Li & Yizhe Wang & Inah Hwang & Ja-Young Jang & Libo Xu & Zhong Deng & Eun Young Yu & Yiming Cai & Caizhi Wu & Zhenbo Han & Yu-Han Huang & Xiangao Huang & Ling Zhang & Jun Yao & Neal F. Lue & Paul , 2023. "Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Ulrik Kristoffer Stoltze & Jon Foss-Skiftesvik & Thomas van Overeem Hansen & Simon Rasmussen & Konrad J. Karczewski & Karin A. W. Wadt & Kjeld Schmiegelow, 2024. "The evolutionary impact of childhood cancer on the human gene pool," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Nneka E. Mbah & Amy L. Myers & Peter Sajjakulnukit & Chan Chung & Joyce K. Thompson & Hanna S. Hong & Heather Giza & Derek Dang & Zeribe C. Nwosu & Mengrou Shan & Stefan R. Sweha & Daniella D. Maydan , 2024. "Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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