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Circadian rhythms persist without transcription in a eukaryote

Author

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  • John S. O’Neill

    (Centre for Systems Biology at Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Gerben van Ooijen

    (Centre for Systems Biology at Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK)

  • Laura E. Dixon

    (Centre for Systems Biology at Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK)

  • Carl Troein

    (School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JH, UK)

  • Florence Corellou

    (UPMC Univ Paris 06, UMR7621 Laboratoire d’Océanographie Microbienne, Observatoire Océanologique, F-66651 Banyuls/mer, France
    CNRS, UMR7621, Laboratoire d’Observatoire d’Océanographie Microbienne, Observatoire Océanologique, F-66651 Banyuls/mer, France)

  • François-Yves Bouget

    (UPMC Univ Paris 06, UMR7621 Laboratoire d’Océanographie Microbienne, Observatoire Océanologique, F-66651 Banyuls/mer, France
    CNRS, UMR7621, Laboratoire d’Observatoire d’Océanographie Microbienne, Observatoire Océanologique, F-66651 Banyuls/mer, France)

  • Akhilesh B. Reddy

    (University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Andrew J. Millar

    (Centre for Systems Biology at Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK
    School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JH, UK)

Abstract

Non-transcriptional circadian rhythms Circadian clocks are critical timing regulators of physiology and behaviour that are ubiquitous in eukaryotes. Most mechanistic models of the clock are based on transcription cycles, but evidence for post-translational regulation has recently surfaced in plants and cyanobacteria. Two groups now demonstrate a role for the oxidation of peroxiredoxin proteins in maintaining an entrainable oscillation in human red blood cells and in the unicellular alga Ostreococcus tauri. These data suggest a role for non-transcriptional mechanisms in clock models and open the door to future work exploring the connections between the transcriptional and non-transcriptional circadian machinery.

Suggested Citation

  • John S. O’Neill & Gerben van Ooijen & Laura E. Dixon & Carl Troein & Florence Corellou & François-Yves Bouget & Akhilesh B. Reddy & Andrew J. Millar, 2011. "Circadian rhythms persist without transcription in a eukaryote," Nature, Nature, vol. 469(7331), pages 554-558, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09654
    DOI: 10.1038/nature09654
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    Cited by:

    1. Margaritis Voliotis & Philipp Thomas & Ramon Grima & Clive G Bowsher, 2016. "Stochastic Simulation of Biomolecular Networks in Dynamic Environments," PLOS Computational Biology, Public Library of Science, vol. 12(6), pages 1-18, June.
    2. El Batoul Djouani-Tahri & Frédéric Sanchez & Jean-Claude Lozano & François-Yves Bouget, 2011. "A Phosphate-Regulated Promoter for Fine-Tuned and Reversible Overexpression in Ostreococcus: Application to Circadian Clock Functional Analysis," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-10, December.

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