IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v83y2016icp223-233.html
   My bibliography  Save this article

Detrended fluctuation analysis of compound action potentials re-corded in the cutaneous nerves of diabetic rats

Author

Listed:
  • Quiroz-González, Salvador
  • Rodríguez-Torres, Erika Elizabeth
  • Segura-Alegría, Bertha
  • Pereira-Venegas, Javier
  • Lopez-Gomez, Rosa Estela
  • Jiménez-Estrada, Ismael

Abstract

The electrophysiological alterations in nerves due to diabetes are classically studied in relation to their instantaneous frequency, conduction velocity and amplitude. However, analysis of amplitude variability may reflect the occurrence of feedback loop mechanisms that adjust the output as a function of its previous activity could indicate fractal dynamics. We assume that a peripheral neuropathy, such as that evoked by diabetes, the inability to maintain a steady flow of sensory information is reflected as a breakdown of the long range power-law correlation of CAP area fluctuation from cutaneous nerves. To test this, we first explored in normal rats whether fluctuations in the trial-to-trial CAP area showed a self-similar behavior or fractal structure by means of detrended fluctuations analysis (DFA), and Poincare plots. In addition, we determine whether such CAP fluctuations varied by diabetes induction. Results showed that CAP area fluctuation of SU nerves evoked in normal rats present a long term correlation and self-similar organization (fractal behavior) from trial to trial stimulation as evidenced by DFA of CAP areas. However, CAPs recorded in diabetic nerves exhibited significant reductions in area, larger duration and increased area variability and different Poincare plots than control nerves. The Hurst exponent value determined with the DFA method from a series of 2000 CAPs evoked in diabetic SU nerves was smaller than in control nerves. It is proposed that in cutaneous nerves of normal rats variability of the CAP area present a long term correlation and self-similar organization (fractal behavior), and reflect the ability to maintain a steady flow of sensory information through cutaneous nerves. Nevertheless, this is not the case for sural nerves of diabetic rats which is reflected as a breakdown of the long range power-law correlation of CAP area fluctuation. Nonlinear time series analysis of CAP area fluctuations is a valuable new insight tool that can be used for the study of alterations in transmission of sensory information in humans suffering diabetes or under other demyelination diseases.

Suggested Citation

  • Quiroz-González, Salvador & Rodríguez-Torres, Erika Elizabeth & Segura-Alegría, Bertha & Pereira-Venegas, Javier & Lopez-Gomez, Rosa Estela & Jiménez-Estrada, Ismael, 2016. "Detrended fluctuation analysis of compound action potentials re-corded in the cutaneous nerves of diabetic rats," Chaos, Solitons & Fractals, Elsevier, vol. 83(C), pages 223-233.
    • Handle: RePEc:eee:chsofr:v:83:y:2016:i:c:p:223-233
    DOI: 10.1016/j.chaos.2015.12.011
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077915004294
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2015.12.011?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Klaus-Armin Nave, 2010. "Myelination and support of axonal integrity by glia," Nature, Nature, vol. 468(7321), pages 244-252, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Panagiotis Fotiadis & Matthew Cieslak & Xiaosong He & Lorenzo Caciagli & Mathieu Ouellet & Theodore D. Satterthwaite & Russell T. Shinohara & Dani S. Bassett, 2023. "Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Alberto Lazari & Piergiorgio Salvan & Lennart Verhagen & Michiel Cottaar & Daniel Papp & Olof Jens van der Werf & Bronwyn Gavine & James Kolasinski & Matthew Webster & Charlotte J. Stagg & Matthew F. , 2022. "A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Yongwoo Kwon & Jin Hee Hong & Sungsam Kang & Hojun Lee & Yonghyeon Jo & Ki Hean Kim & Seokchan Yoon & Wonshik Choi, 2023. "Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:83:y:2016:i:c:p:223-233. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.