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Fine-scale recombination rate differences between sexes, populations and individuals

Author

Listed:
  • Augustine Kong

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Gudmar Thorleifsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Daniel F. Gudbjartsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Gisli Masson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Asgeir Sigurdsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Aslaug Jonasdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • G. Bragi Walters

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Adalbjorg Jonasdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Arnaldur Gylfason

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Kari Th. Kristinsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Sigurjon A. Gudjonsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Michael L. Frigge

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland)

  • Agnar Helgason

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
    University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland)

  • Unnur Thorsteinsdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
    Faculty of Medicine, University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland)

  • Kari Stefansson

    (deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
    Faculty of Medicine, University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland)

Abstract

Recombination maps reveal differences between the sexes High-resolution recombination maps serve many purposes in genetic research. The currently available maps, which use linkage disequilibrium patterns of high-density SNP (single nucleotide polymorphism) data from the HapMap project, have proved to be very useful. But they have some limitations; for instance, they do not provide information on differences in recombination characteristics between and within the sexes. A team at biopharmaceutical firm deCODE genetics in Reykjavik has used genome-wide SNP data from more than 15,000 parent–offspring pairs to construct the first recombination maps based on directly observed recombination events, providing resolution down to 10 kilobases. Their data reveal interesting recombination differences between the sexes. In males, for example, recombination tends to shuffle exons, whereas in females it generates new combinations of nearby genes. Comparisons of these maps with those based on linkage disequilibrium reveal previously unrecognized differences between populations in Europe, Africa and the United States.

Suggested Citation

  • Augustine Kong & Gudmar Thorleifsson & Daniel F. Gudbjartsson & Gisli Masson & Asgeir Sigurdsson & Aslaug Jonasdottir & G. Bragi Walters & Adalbjorg Jonasdottir & Arnaldur Gylfason & Kari Th. Kristins, 2010. "Fine-scale recombination rate differences between sexes, populations and individuals," Nature, Nature, vol. 467(7319), pages 1099-1103, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7319:d:10.1038_nature09525
    DOI: 10.1038/nature09525
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    Citations

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    Cited by:

    1. Andrew H Chan & Paul A Jenkins & Yun S Song, 2012. "Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster," PLOS Genetics, Public Library of Science, vol. 8(12), pages 1-28, December.
    2. Lauren A. Choate & Gilad Barshad & Pierce W. McMahon & Iskander Said & Edward J. Rice & Paul R. Munn & James J. Lewis & Charles G. Danko, 2021. "Multiple stages of evolutionary change in anthrax toxin receptor expression in humans," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Benjamin J. Schmiedel & Job Rocha & Cristian Gonzalez-Colin & Sourya Bhattacharyya & Ariel Madrigal & Christian H. Ottensmeier & Ferhat Ay & Vivek Chandra & Pandurangan Vijayanand, 2021. "COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Julian Petersen & Lukas Englmaier & Artem V. Artemov & Irina Poverennaya & Ruba Mahmoud & Thibault Bouderlique & Marketa Tesarova & Ruslan Deviatiiarov & Anett Szilvásy-Szabó & Evgeny E. Akkuratov & D, 2023. "A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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