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Molecular robots guided by prescriptive landscapes

Author

Listed:
  • Kyle Lund

    (Arizona State University, Tempe, Arizona 85287, USA
    The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA)

  • Anthony J. Manzo

    (Single Molecule Analysis Group, University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Nadine Dabby

    (Computation & Neural Systems, California Institute of Technology, Pasadena, California 91125, USA)

  • Nicole Michelotti

    (Single Molecule Analysis Group, University of Michigan, Ann Arbor, Michigan 48109, USA
    University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Alexander Johnson-Buck

    (Single Molecule Analysis Group, University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Jeanette Nangreave

    (Arizona State University, Tempe, Arizona 85287, USA
    The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA)

  • Steven Taylor

    (Columbia University, New York, New York 10032, USA)

  • Renjun Pei

    (Columbia University, New York, New York 10032, USA)

  • Milan N. Stojanovic

    (Columbia University, New York, New York 10032, USA
    Columbia University, New York, New York 10032, USA)

  • Nils G. Walter

    (Single Molecule Analysis Group, University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Erik Winfree

    (Computation & Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Computer Science, California Institute of Technology, Pasadena, California 91125, USA
    Bioengineering, California Institute of Technology, Pasadena, California 91125, USA)

  • Hao Yan

    (Arizona State University, Tempe, Arizona 85287, USA
    The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA)

Abstract

Robotics in the nanoworld Programming the behaviour of molecules in time and space is a big challenge in nanotechnology. Traditional robots can be given a memory in which to store internal representations of their goals and environment, and coordinate their response. Individual molecules are limited in their ability to store information and programs, but robotic behaviour can still be realized by exploiting the interaction of simple single-molecule robots with a precisely defined environment. This has now been demonstrated with spider-shaped DNA 'walkers', which sense and modify tracks of substrate molecules laid out on a two-dimensional DNA origami landscape. The robots carry out actions such as 'start', 'follow', 'turn', and 'stop' programmed into the DNA landscape, with more complex robotic behaviour expected once secondary levels of control can be introduced.

Suggested Citation

  • Kyle Lund & Anthony J. Manzo & Nadine Dabby & Nicole Michelotti & Alexander Johnson-Buck & Jeanette Nangreave & Steven Taylor & Renjun Pei & Milan N. Stojanovic & Nils G. Walter & Erik Winfree & Hao Y, 2010. "Molecular robots guided by prescriptive landscapes," Nature, Nature, vol. 465(7295), pages 206-210, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7295:d:10.1038_nature09012
    DOI: 10.1038/nature09012
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    Citations

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    Cited by:

    1. Vishal Maingi & Zhao Zhang & Chris Thachuk & Namita Sarraf & Edwin R. Chapman & Paul W. K. Rothemund, 2023. "Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Hong Kang & Yuexuan Yang & Bryan Wei, 2024. "Synthetic molecular switches driven by DNA-modifying enzymes," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    3. Elena Agliari & Adriano Barra & Giulio Landolfi & Sara Murciano & Sarah Perrone, 2018. "Complex Reaction Kinetics in Chemistry: A Unified Picture Suggested by Mechanics in Physics," Complexity, Hindawi, vol. 2018, pages 1-16, January.
    4. Chapin S. Korosec & Ivan N. Unksov & Pradheebha Surendiran & Roman Lyttleton & Paul M. G. Curmi & Christopher N. Angstmann & Ralf Eichhorn & Heiner Linke & Nancy R. Forde, 2024. "Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Sungwook Woo & Sinem K. Saka & Feng Xuan & Peng Yin, 2024. "Molecular robotic agents that survey molecular landscapes for information retrieval," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    6. Alexandru Amărioarei & Frankie Spencer & Gefry Barad & Ana-Maria Gheorghe & Corina Iţcuş & Iris Tuşa & Ana-Maria Prelipcean & Andrei Păun & Mihaela Păun & Alfonso Rodriguez-Paton & Romică Trandafir & , 2021. "DNA-Guided Assembly for Fibril Proteins," Mathematics, MDPI, vol. 9(4), pages 1-17, February.

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