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Expansion of the eukaryotic proteome by alternative splicing

Author

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  • Timothy W. Nilsen

    (Center for RNA Molecular Biology, Case Western Reserve University, School of Medicine)

  • Brenton R. Graveley

    (University of Connecticut Stem Cell Institute, University of Connecticut Health Center)

Abstract

The collection of components required to carry out the intricate processes involved in generating and maintaining a living, breathing and, sometimes, thinking organism is staggeringly complex. Where do all of the parts come from? Early estimates stated that about 100,000 genes would be required to make up a mammal; however, the actual number is less than one-quarter of that, barely four times the number of genes in budding yeast. It is now clear that the 'missing' information is in large part provided by alternative splicing, the process by which multiple different functional messenger RNAs, and therefore proteins, can be synthesized from a single gene.

Suggested Citation

  • Timothy W. Nilsen & Brenton R. Graveley, 2010. "Expansion of the eukaryotic proteome by alternative splicing," Nature, Nature, vol. 463(7280), pages 457-463, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08909
    DOI: 10.1038/nature08909
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    Cited by:

    1. Timofey A. Karginov & Antoine Ménoret & Anthony T. Vella, 2022. "Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Komal Soni & Pravin Kumar Ankush Jagtap & Santiago Martínez-Lumbreras & Sophie Bonnal & Arie Geerlof & Ralf Stehle & Bernd Simon & Juan Valcárcel & Michael Sattler, 2023. "Structural basis for specific RNA recognition by the alternative splicing factor RBM5," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Santiago, Enrique, 2015. "Probability and time to fixation of an evolving sequence," Theoretical Population Biology, Elsevier, vol. 104(C), pages 78-85.
    4. Huijuan Feng & Xiang-Jun Lu & Suvrajit Maji & Linxi Liu & Dmytro Ustianenko & Noam D. Rudnick & Chaolin Zhang, 2024. "Structure-based prediction and characterization of photo-crosslinking in native protein–RNA complexes," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Feng Wang & Yang Xu & Robert Wang & Beatrice Zhang & Noah Smith & Amber Notaro & Samantha Gaerlan & Eric Kutschera & Kathryn E. Kadash-Edmondson & Yi Xing & Lan Lin, 2023. "TEQUILA-seq: a versatile and low-cost method for targeted long-read RNA sequencing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Zhiyi Qin & Xuegong Zhang, 2017. "The identification of switch-like alternative splicing exons among multiple samples with RNA-Seq data," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-12, May.
    7. Adel Al Jord & Gaëlle Letort & Soline Chanet & Feng-Ching Tsai & Christophe Antoniewski & Adrien Eichmuller & Christelle Da Silva & Jean-René Huynh & Nir S. Gov & Raphaël Voituriez & Marie-Émilie Terr, 2022. "Cytoplasmic forces functionally reorganize nuclear condensates in oocytes," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    8. Nicholas C. Gervais & Rebecca S. Shapiro, 2024. "Discovering the hidden function in fungal genomes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    9. Yocelyn Recinos & Dmytro Ustianenko & Yow-Tyng Yeh & Xiaojian Wang & Martin Jacko & Lekha V. Yesantharao & Qiyang Wu & Chaolin Zhang, 2024. "CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    10. Shenglei Feng & Jinmei Li & Hui Wen & Kuan Liu & Yiqian Gui & Yujiao Wen & Xiaoli Wang & Shuiqiao Yuan, 2022. "hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    11. Dena Leshkowitz & Ester Feldmesser & Gilgi Friedlander & Ghil Jona & Elena Ainbinder & Yisrael Parmet & Shirley Horn-Saban, 2016. "Using Synthetic Mouse Spike-In Transcripts to Evaluate RNA-Seq Analysis Tools," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-20, April.
    12. Shijia Zhu & Guohua Wang & Bo Liu & Yadong Wang, 2013. "Modeling Exon Expression Using Histone Modifications," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-15, June.

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