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Stably maintained dendritic spines are associated with lifelong memories

Author

Listed:
  • Guang Yang

    (Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA)

  • Feng Pan

    (Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA)

  • Wen-Biao Gan

    (Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA)

Abstract

Synapse structure in memory: plasticity and stability Connections between neurons are thought to be remodelled when we learn new tasks or acquire new information. However, this plasticity must also occur against a backdrop of stable memory maintenance. In mice, a paradigm of either enhanced sensory experience or specific motor learning produced new putative neuronal connections that remained stable alongside developmentally preserved connections much later in life. This suggests that learning can produce changes in the neuronal connectivity that can be stable for the lifetime of the network.

Suggested Citation

  • Guang Yang & Feng Pan & Wen-Biao Gan, 2009. "Stably maintained dendritic spines are associated with lifelong memories," Nature, Nature, vol. 462(7275), pages 920-924, December.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7275:d:10.1038_nature08577
    DOI: 10.1038/nature08577
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    Citations

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    Cited by:

    1. Francesco Paolo Ulloa Severino & Oluwadamilola O. Lawal & Kristina Sakers & Shiyi Wang & Namsoo Kim & Alexander David Friedman & Sarah Anne Johnson & Chaichontat Sriworarat & Ryan H. Hughes & Scott H., 2023. "Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Chao Chen & Linlin Sun & Avital Adler & Hang Zhou & Licheng Zhang & Lihai Zhang & Junhao Deng & Yang Bai & Jinhui Zhang & Guang Yang & Wen-Biao Gan & Peifu Tang, 2023. "Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Christopher M. Kim & Arseny Finkelstein & Carson C. Chow & Karel Svoboda & Ran Darshan, 2023. "Distributing task-related neural activity across a cortical network through task-independent connections," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Ayush Mandwal & Javier G Orlandi & Christoph Simon & Jörn Davidsen, 2021. "A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-34, May.
    5. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-22, December.
    6. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    7. Zhiwei Xu & Erez Geron & Luis M. Pérez-Cuesta & Yang Bai & Wen-Biao Gan, 2023. "Generalized extinction of fear memory depends on co-allocation of synaptic plasticity in dendrites," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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