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Rapid formation and selective stabilization of synapses for enduring motor memories

Author

Listed:
  • Tonghui Xu

    (Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA)

  • Xinzhu Yu

    (Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA)

  • Andrew J. Perlik

    (Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA)

  • Willie F. Tobin

    (Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA)

  • Jonathan A. Zweig

    (Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA)

  • Kelly Tennant

    (Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA)

  • Theresa Jones

    (Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA)

  • Yi Zuo

    (Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA)

Abstract

Synapse structure in memory: changes within hours Long-term memories for motor skill tasks are associated with enhanced synaptic efficacy in the motor cortex. Here, rapid structural responses in individual neurons are revealed to potentially underlie motor learning skill retention. In experiments in which mice were trained to perform a reaching task, new neuronal spines were selectively stabilized within hours, with different spines/putative synapse sets encoding distinct learned motor skills. These stabilized morphological changes are proposed to act as a motor memory substrate.

Suggested Citation

  • Tonghui Xu & Xinzhu Yu & Andrew J. Perlik & Willie F. Tobin & Jonathan A. Zweig & Kelly Tennant & Theresa Jones & Yi Zuo, 2009. "Rapid formation and selective stabilization of synapses for enduring motor memories," Nature, Nature, vol. 462(7275), pages 915-919, December.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7275:d:10.1038_nature08389
    DOI: 10.1038/nature08389
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    Cited by:

    1. Sanne Ten Oever & Alexander T. Sack & Carina R. Oehrn & Nikolai Axmacher, 2021. "An engram of intentionally forgotten information," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Francesco Paolo Ulloa Severino & Oluwadamilola O. Lawal & Kristina Sakers & Shiyi Wang & Namsoo Kim & Alexander David Friedman & Sarah Anne Johnson & Chaichontat Sriworarat & Ryan H. Hughes & Scott H., 2023. "Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Joanna C. Chang & Matthew G. Perich & Lee E. Miller & Juan A. Gallego & Claudia Clopath, 2024. "De novo motor learning creates structure in neural activity that shapes adaptation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Christopher M. Kim & Arseny Finkelstein & Carson C. Chow & Karel Svoboda & Ran Darshan, 2023. "Distributing task-related neural activity across a cortical network through task-independent connections," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Tamir Eisenstein & Edna Furman-Haran & Assaf Tal, 2024. "Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Barbara Feulner & Matthew G. Perich & Raeed H. Chowdhury & Lee E. Miller & Juan A. Gallego & Claudia Clopath, 2022. "Small, correlated changes in synaptic connectivity may facilitate rapid motor learning," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    8. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-22, December.
    9. Moritz Deger & Moritz Helias & Stefan Rotter & Markus Diesmann, 2012. "Spike-Timing Dependence of Structural Plasticity Explains Cooperative Synapse Formation in the Neocortex," PLOS Computational Biology, Public Library of Science, vol. 8(9), pages 1-13, September.
    10. Eleni Mitsea & Athanasios Drigas & Charalabos Skianis, 2022. "ICTs and Speed Learning in Special Education: High-Consciousness Training Strategies for High-Capacity Learners through Metacognition Lens," Technium Social Sciences Journal, Technium Science, vol. 27(1), pages 230-252, January.

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