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Contact inhibition of locomotion in vivo controls neural crest directional migration

Author

Listed:
  • Carlos Carmona-Fontaine

    (University College London)

  • Helen K. Matthews

    (University College London)

  • Sei Kuriyama

    (University College London)

  • Mauricio Moreno

    (University College London)

  • Graham A. Dunn

    (King’s College London)

  • Maddy Parsons

    (King’s College London)

  • Claudio D. Stern

    (University College London)

  • Roberto Mayor

    (University College London)

Abstract

Close cellular encounters: neural crest cells prove a point The phenomenon of contact inhibition of cell movement (or locomotion) was first identified more than 50 years ago in fibroblast cells in vitro, and defective contact inhibition is suggested as a factor in malignant cell invasiveness. It occurs when two cells touch; they retract their protrusions and change their direction of movement. But the molecular basis of this inhibition, and whether it happens in vivo, are still matters of controversy. Now time-lapse microscopy of neural crest cells, highly migratory cells of embryonic origin, has been used to demonstrate contact inhibition of locomotion both in vivo and in vitro, and that it can account for their directional migration. But when a neural crest cell meets another cell type it fails to display contact inhibition of locomotion, allowing it to invade the tissue.

Suggested Citation

  • Carlos Carmona-Fontaine & Helen K. Matthews & Sei Kuriyama & Mauricio Moreno & Graham A. Dunn & Maddy Parsons & Claudio D. Stern & Roberto Mayor, 2008. "Contact inhibition of locomotion in vivo controls neural crest directional migration," Nature, Nature, vol. 456(7224), pages 957-961, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07441
    DOI: 10.1038/nature07441
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    Cited by:

    1. Christine Chiasson-MacKenzie & Jeremie Vitte & Ching-Hui Liu & Emily A. Wright & Elizabeth A. Flynn & Shannon L. Stott & Marco Giovannini & Andrea I. McClatchey, 2023. "Cellular mechanisms of heterogeneity in NF2-mutant schwannoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Aleksandr Vasilyev & Yan Liu & Nathan Hellman & Narendra Pathak & Iain A Drummond, 2012. "Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-11, July.
    3. András Szabó & Eric Theveneau & Melissa Turan & Roberto Mayor, 2019. "Neural crest streaming as an emergent property of tissue interactions during morphogenesis," PLOS Computational Biology, Public Library of Science, vol. 15(4), pages 1-21, April.
    4. Masataka Yamao & Honda Naoki & Shin Ishii, 2011. "Multi-Cellular Logistics of Collective Cell Migration," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-11, December.
    5. Agustin D. Pizarro & Claudio L. A. Berli & Galo J. A. A. Soler-Illia & Martín G. Bellino, 2022. "Droplets in underlying chemical communication recreate cell interaction behaviors," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    6. Matthew A. Heinrich & Ricard Alert & Abraham E. Wolf & Andrej Košmrlj & Daniel J. Cohen, 2022. "Self-assembly of tessellated tissue sheets by expansion and collision," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    7. Yassine El Bakkouri & Rony Chidiac & Chantal Delisle & Jeanne Corriveau & Gael Cagnone & Vanda Gaonac’h-Lovejoy & Ashley Chin & Éric Lécuyer & Stephane Angers & Jean-Sébastien Joyal & Ivan Topisirovic, 2024. "ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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