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RNA interference screen for human genes associated with West Nile virus infection

Author

Listed:
  • Manoj N. Krishnan

    (Section of Infectious Diseases,)

  • Aylwin Ng

    (Center for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Bindu Sukumaran

    (Section of Infectious Diseases,)

  • Felicia D. Gilfoy

    (University of Texas Medical Branch, Galveston, Texas 77555, USA)

  • Pradeep D. Uchil

    (Section for Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticutt 06520-8031, USA)

  • Hameeda Sultana

    (Section of Infectious Diseases,)

  • Abraham L. Brass

    (Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Rachel Adametz

    (Section for Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticutt 06520-8031, USA)

  • Melody Tsui

    (Department of Systems Biology,)

  • Feng Qian

    (Section of Rheumatology)

  • Ruth R. Montgomery

    (Section of Rheumatology)

  • Sima Lev

    (Weizmann Institute of Science)

  • Peter W. Mason

    (University of Texas Medical Branch, Galveston, Texas 77555, USA)

  • Raymond A. Koski

    (L2 Diagnostics, 300 George Street, New Haven, Connecticutt 06511, USA)

  • Stephen J. Elledge

    (Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, USA)

  • Ramnik J. Xavier

    (Center for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Herve Agaisse

    (Section for Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticutt 06520-8031, USA)

  • Erol Fikrig

    (Section of Infectious Diseases,
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, USA)

Abstract

West Nile virus: interaction with human cells This manuscript reports a comprehensive systems level description of the molecular signatures governing the interaction of West Nile virus with human cells. A whole-genome human RNA interference gene silencing screen in HeLa cells identified 305 host proteins genes that facilitate West Nile virus infection of human cells. A number of the identified also play a role in the infection of dengue virus, another flavivirus related to West Nile virus. This work highlights differences in the molecular pathogenesis of related flaviviruses, and points to several possible new targets for antiviral drugs

Suggested Citation

  • Manoj N. Krishnan & Aylwin Ng & Bindu Sukumaran & Felicia D. Gilfoy & Pradeep D. Uchil & Hameeda Sultana & Abraham L. Brass & Rachel Adametz & Melody Tsui & Feng Qian & Ruth R. Montgomery & Sima Lev &, 2008. "RNA interference screen for human genes associated with West Nile virus infection," Nature, Nature, vol. 455(7210), pages 242-245, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7210:d:10.1038_nature07207
    DOI: 10.1038/nature07207
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    Citations

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    Cited by:

    1. Linhui Hao & Qiuling He & Zhishi Wang & Mark Craven & Michael A Newton & Paul Ahlquist, 2013. "Limited Agreement of Independent RNAi Screens for Virus-Required Host Genes Owes More to False-Negative than False-Positive Factors," PLOS Computational Biology, Public Library of Science, vol. 9(9), pages 1-20, September.
    2. T M Murali & Matthew D Dyer & David Badger & Brett M Tyler & Michael G Katze, 2011. "Network-Based Prediction and Analysis of HIV Dependency Factors," PLOS Computational Biology, Public Library of Science, vol. 7(9), pages 1-15, September.
    3. Casey S Greene & Olga G Troyanskaya, 2012. "Chapter 2: Data-Driven View of Disease Biology," PLOS Computational Biology, Public Library of Science, vol. 8(12), pages 1-8, December.
    4. Deborah Chasman & Brandi Gancarz & Linhui Hao & Michael Ferris & Paul Ahlquist & Mark Craven, 2014. "Inferring Host Gene Subnetworks Involved in Viral Replication," PLOS Computational Biology, Public Library of Science, vol. 10(5), pages 1-22, May.
    5. Abigail W Bigham & Kati J Buckingham & Sofia Husain & Mary J Emond & Kathryn M Bofferding & Heidi Gildersleeve & Ann Rutherford & Natalia M Astakhova & Andrey A Perelygin & Michael P Busch & Kristy O , 2011. "Host Genetic Risk Factors for West Nile Virus Infection and Disease Progression," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-11, September.

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