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Nanog safeguards pluripotency and mediates germline development

Author

Listed:
  • Ian Chambers

    (MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK)

  • Jose Silva

    (Wellcome Trust Centre for Stem Cell Research,
    and)

  • Douglas Colby

    (MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK)

  • Jennifer Nichols

    (Wellcome Trust Centre for Stem Cell Research,
    Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Bianca Nijmeijer

    (MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK)

  • Morag Robertson

    (MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK)

  • Jan Vrana

    (MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK)

  • Ken Jones

    (Wellcome Trust Centre for Stem Cell Research,
    Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Lars Grotewold

    (MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK)

  • Austin Smith

    (Wellcome Trust Centre for Stem Cell Research,
    and)

Abstract

Nanog changes tack In 2003 the transcription factor Nanog was identified as a key contributor to the property that makes embryonic stem cells unique: pluripotency. Nanog, named after Tir nan Og, the 'land of the forever-young' of Celtic myth, was thought to be required for stem cells to multiply while retaining the potential to differentiate. New work in mouse embryonic stem cells suggests a rather different picture. In fact Nanog is not essential for maintaining pluripotency; its levels fluctuate, but Nanog appears to stabilize the pluripotent state by resisting or reversing alternative states of gene expression.

Suggested Citation

  • Ian Chambers & Jose Silva & Douglas Colby & Jennifer Nichols & Bianca Nijmeijer & Morag Robertson & Jan Vrana & Ken Jones & Lars Grotewold & Austin Smith, 2007. "Nanog safeguards pluripotency and mediates germline development," Nature, Nature, vol. 450(7173), pages 1230-1234, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7173:d:10.1038_nature06403
    DOI: 10.1038/nature06403
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    Citations

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    Cited by:

    1. Gemma Noviello & Rutger A. F. Gjaltema & Edda G. Schulz, 2023. "CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Sivakamasundari Vijayakumar & Roberta Sala & Gugene Kang & Angela Chen & Michelle Ann Pablo & Abidemi Ismail Adebayo & Andrea Cipriano & Jonas L. Fowler & Danielle L. Gomes & Lay Teng Ang & Kyle M. Lo, 2023. "Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Najme Khorasani & Mehdi Sadeghi & Abbas Nowzari-Dalini, 2020. "A computational model of stem cell molecular mechanism to maintain tissue homeostasis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-25, July.
    4. Rohith Palli & Mukta G Palshikar & Juilee Thakar, 2019. "Executable pathway analysis using ensemble discrete-state modeling for large-scale data," PLOS Computational Biology, Public Library of Science, vol. 15(9), pages 1-21, September.
    5. Margaret J Tse & Brian K Chu & Cameron P Gallivan & Elizabeth L Read, 2018. "Rare-event sampling of epigenetic landscapes and phenotype transitions," PLOS Computational Biology, Public Library of Science, vol. 14(8), pages 1-28, August.
    6. Colin T Maguire & Bradley L Demarest & Jonathon T Hill & James D Palmer & Arthur R Brothman & H Joseph Yost & Maureen L Condic, 2013. "Genome-Wide Analysis Reveals the Unique Stem Cell Identity of Human Amniocytes," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-16, January.
    7. Suzanne Gaudet & Sabrina L Spencer & William W Chen & Peter K Sorger, 2012. "Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis," PLOS Computational Biology, Public Library of Science, vol. 8(4), pages 1-15, April.
    8. Zhongxing Sun & Yin Tang & Yanjun Zhang & Yuan Fang & Junqi Jia & Weiwu Zeng & Dong Fang, 2021. "Joint single-cell multiomic analysis in Wnt3a induced asymmetric stem cell division," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    9. Nicolas Allègre & Sabine Chauveau & Cynthia Dennis & Yoan Renaud & Dimitri Meistermann & Lorena Valverde Estrella & Pierre Pouchin & Michel Cohen-Tannoudji & Laurent David & Claire Chazaud, 2022. "NANOG initiates epiblast fate through the coordination of pluripotency genes expression," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. Peter D Tonge & Victor Olariu & Daniel Coca & Visakan Kadirkamanathan & Kelly E Burrell & Stephen A Billings & Peter W Andrews, 2010. "Prepatterning in the Stem Cell Compartment," PLOS ONE, Public Library of Science, vol. 5(5), pages 1-10, May.

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