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Mechanism of coupled folding and binding of an intrinsically disordered protein

Author

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  • Kenji Sugase

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Suntory Institute for Bioorganic Research, 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan)

  • H. Jane Dyson

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Peter E. Wright

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Many proteins that are important to cellular signalling are intrinsically disordered, as they only fold after binding with signalling partners. In this paper the molecular interactions governing such proteins' coupled folding and binding process, and how they differ radically from interactions between pre-folded proteins are described.

Suggested Citation

  • Kenji Sugase & H. Jane Dyson & Peter E. Wright, 2007. "Mechanism of coupled folding and binding of an intrinsically disordered protein," Nature, Nature, vol. 447(7147), pages 1021-1025, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7147:d:10.1038_nature05858
    DOI: 10.1038/nature05858
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    Citations

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    Cited by:

    1. Avner Schlessinger & Marco Punta & Guy Yachdav & Laszlo Kajan & Burkhard Rost, 2009. "Improved Disorder Prediction by Combination of Orthogonal Approaches," PLOS ONE, Public Library of Science, vol. 4(2), pages 1-10, February.
    2. Iskra Staneva & Yongqi Huang & Zhirong Liu & Stefan Wallin, 2012. "Binding of Two Intrinsically Disordered Peptides to a Multi-Specific Protein: A Combined Monte Carlo and Molecular Dynamics Study," PLOS Computational Biology, Public Library of Science, vol. 8(9), pages 1-9, September.
    3. Wenzhe Liu & Limin Chen & Dongbao Yin & Zhiheng Yang & Jianfei Feng & Qi Sun & Luhua Lai & Xuefeng Guo, 2023. "Visualizing single-molecule conformational transition and binding dynamics of intrinsically disordered proteins," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Kalyan S. Chakrabarti & Simon Olsson & Supriya Pratihar & Karin Giller & Kerstin Overkamp & Ko On Lee & Vytautas Gapsys & Kyoung-Seok Ryu & Bert L. Groot & Frank Noé & Stefan Becker & Donghan Lee & Th, 2022. "A litmus test for classifying recognition mechanisms of transiently binding proteins," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Michael Knott & Robert B Best, 2012. "A Preformed Binding Interface in the Unbound Ensemble of an Intrinsically Disordered Protein: Evidence from Molecular Simulations," PLOS Computational Biology, Public Library of Science, vol. 8(7), pages 1-10, July.

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