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Mechanisms of sensory transduction in the skin

Author

Listed:
  • Ellen A. Lumpkin

    (Molecular Physiology & Biophysics and Molecular & Human Genetics, Baylor College of Medicine, One Baylor Plaza)

  • Michael J. Caterina

    (and the Center for Sensory Biology, The Johns Hopkins School of Medicine)

Abstract

Sensory neurons innervating the skin encode the familiar sensations of temperature, touch and pain. An explosion of progress has revealed unanticipated cellular and molecular complexity in these senses. It is now clear that perception of a single stimulus, such as heat, requires several transduction mechanisms. Conversely, a given protein may contribute to multiple senses, such as heat and touch. Recent studies have also led to the surprising insight that skin cells might transduce temperature and touch. To break the code underlying somatosensation, we must therefore understand how the skin's sensory functions are divided among signalling molecules and cell types.

Suggested Citation

  • Ellen A. Lumpkin & Michael J. Caterina, 2007. "Mechanisms of sensory transduction in the skin," Nature, Nature, vol. 445(7130), pages 858-865, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7130:d:10.1038_nature05662
    DOI: 10.1038/nature05662
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    Cited by:

    1. Xiaojie Cai & Maoying Han & Fangzhou Lou & Yang Sun & Qianqian Yin & Libo Sun & Zhikai Wang & Xiangxiao Li & Hong Zhou & Zhenyao Xu & Hong Wang & Siyu Deng & Xichen Zheng & Taiyu Zhang & Qun Li & Bin , 2023. "Tenascin C+ papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Sayan Chakraborty & Divyaleka Sampath & Melissa Ong Yu Lin & Matthew Bilton & Cheng-Kuang Huang & Mui Hoon Nai & Kizito Njah & Pierre-Alexis Goy & Cheng-Chun Wang & Ernesto Guccione & Chwee-Teck Lim &, 2021. "Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Min Jung & Michelle Dourado & James Maksymetz & Amanda Jacobson & Benjamin I. Laufer & Miriam Baca & Oded Foreman & David H. Hackos & Lorena Riol-Blanco & Joshua S. Kaminker, 2023. "Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Jinchul Ahn & Kyungeun Ohk & Jihee Won & Dong-Hee Choi & Yong Hun Jung & Ji Hun Yang & Yesl Jun & Jin-A Kim & Seok Chung & Sang-Hoon Lee, 2023. "Modeling of three-dimensional innervated epidermal like-layer in a microfluidic chip-based coculture system," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Feipeng Chen & Xiufeng Li & Yafeng Yu & Qingchuan Li & Haisong Lin & Lizhi Xu & Ho Cheung Shum, 2023. "Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Liansheng Liu & Hua Yang & Runze Duan & Minghai Liu & Ruifang Zhang & Yiji Ding & Hongzhen Sun, 2018. "Effect of Non-Coal Heating and Traditional Heating on Indoor Environment of Rural Houses in Tianjin," IJERPH, MDPI, vol. 16(1), pages 1-10, December.

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